Comparative epidemiological analysis on two-batch study of breast cancer in Dr. Cipto Mangunkusumo Hospital, Jakarta – Indonesia

In order to analyze various risk factor in breast cancer among Indonesian women, epidemiologic studies were performed in two batches, using standard case-control study method. Three hundreds breast cancer cases were compared to 600 matched controls during the first batch study in 1988-1991 and 226 cases were compared to 252 controls during the second batch study in 1992-1995. The data were analyzed by calculating the Odds Ratios for determining the significance of various risk factors, and both univariate and multivariate analysis were performed. The findings were evaluated for their consistency between the two studies. The first batch study showed that several risk factors significantly increased the risk in both univariate and multivariate analysis, i.e. late menarche, breast trauma, menopause, short lactation, high fat consumption, while high protein intake increased the risk only in univariate analysis. They were not significantly shown in the second batch study.