TY - JOUR
T1 - Comparative effects of curcumin and nanocurcumin on cisplatin-induced Acute Kidney Injury
AU - Sumbung, Nielda Kezia
AU - Waworuntu, Bernardino Matthew
AU - Soetikno, Vivian
AU - Louisa, Melva
N1 - Funding Information:
We thank Department of Pharmacology and Therapeutics for the support to finish this research. We also thank Dr Paramitha, M. Biomed and Bantari Wisnu M. for their support during this research. This research is funded by Universitas Indonesia through PITTA grant. The publication of this manuscript is supported by Universitas Indonesia.
Publisher Copyright:
© 2019 Journal of International Dental and Medical Research.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Cisplatin is a highly efficacious chemotherapeutic drug; however, it can trigger nephrotoxicity. Previous studies have suggested that curcumin can protect kidneys from cisplatin-induced toxicity. However, its low bioavailability hampers its usage. This study aimed to evaluate the effect of different nanocurcumin concentrations on cisplatin-induced acute kidney injury in rats. Sprague Dawley rats were randomly divided into five groups, each receiving a different treatment for 9 days: normal, cisplatin, cisplatin + curcumin, cisplatin+nanocurcumin50, and cisplatin+nanocurcumin100. Kidney and plasma samples were analyzed. A larger concentration of curcumin was detected in the kidneys of the curcumin-treated group than in the nanocurcumin-treated groups, however no statistically significant differences between groups. The concentration of nanocurcumin in the kidneys of the group treated with cisplatin + nanocurcumin 50 mg/kgBW group was higher than in those treated with cisplatin + nanocurcumin 100 mg/kgBW group. These results are consistent with the expression levels of kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL) in kidney, as both these genes were expressed at lower levels in the nanocurcumin 50 mg/kgBW. We conclude that nanocurcumin at a dose of 50 mg/kgBW might protect the kidney against cisplatin-induced damage through decreased levels of KIM1 and NGAL.
AB - Cisplatin is a highly efficacious chemotherapeutic drug; however, it can trigger nephrotoxicity. Previous studies have suggested that curcumin can protect kidneys from cisplatin-induced toxicity. However, its low bioavailability hampers its usage. This study aimed to evaluate the effect of different nanocurcumin concentrations on cisplatin-induced acute kidney injury in rats. Sprague Dawley rats were randomly divided into five groups, each receiving a different treatment for 9 days: normal, cisplatin, cisplatin + curcumin, cisplatin+nanocurcumin50, and cisplatin+nanocurcumin100. Kidney and plasma samples were analyzed. A larger concentration of curcumin was detected in the kidneys of the curcumin-treated group than in the nanocurcumin-treated groups, however no statistically significant differences between groups. The concentration of nanocurcumin in the kidneys of the group treated with cisplatin + nanocurcumin 50 mg/kgBW group was higher than in those treated with cisplatin + nanocurcumin 100 mg/kgBW group. These results are consistent with the expression levels of kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL) in kidney, as both these genes were expressed at lower levels in the nanocurcumin 50 mg/kgBW. We conclude that nanocurcumin at a dose of 50 mg/kgBW might protect the kidney against cisplatin-induced damage through decreased levels of KIM1 and NGAL.
KW - Bioavailability
KW - Cisplatin
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85069484493&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85069484493
VL - 12
SP - 803
EP - 808
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
SN - 1309-100X
IS - 2
ER -