Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer

Stephen Chee Liang Koh, Yiong Huak Chan, Delfi Lutan, Johny Marpuang, Suwiyoga Ketut, Nyoma Gede Budiana, Agustria Zainu Saleh, Mohd Farid Aziz, Hariyono Winarto, Heru Pradjatmo, Nguyen Khac Han Hoan, Pham Viet Thanh, Mahesh Choolani

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Objective: To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer. Methods: Serum specimens collected from 5 Indonesian centers and 1 Vietnamese center were analyzed for CA-125, hK6, and hK10 levels. A total of 375 specimens from patients presenting with ovarian tumors, which include 156 benign cysts, 172 epithelial ovarian cancers (stage I/II, n=72; stage III/IV, n=100), 36 germ cell tumors and 11 borderline tumors, were included in the study analysis. Receiver operating characteristic analysis were performed to determine the cutoffs for age, CA-125, hK6, and hK10. Sensitivity, specificity, negative, and positive predictive values were determined for various combinations of the biomarkers. Results: The levels of hK6 and hK10 were significantly elevated in ovarian cancer cases compared to benign cysts. Combination of 3 markers, age/CA-125/hk6 or CA-125/hk6/hk10, showed improved specificity (100%) and positive predictive value (100%) for prediction of ovarian cancer, when compared to the performance of single markers having 80-92% specificity and 74-87% positive predictive value. Four-marker combination, age/CA-125/hK6/hK10 also showed 100% specificity and 100% positive predictive value, although it demonstrated low sensitivity (11.9%) and negative predictive value (52.8%). Conclusion: The combination of human tissue kallikreins and CA-125 showed potential for improving prediction of epithelial ovarian cancer in patients presenting with ovarian tumors.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalJournal of Gynecologic Oncology
Volume23
Issue number3
DOIs
Publication statusPublished - 1 Jun 2012

Keywords

  • Age
  • Epithelial ovarian cancer
  • Tumor markers

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