TY - JOUR
T1 - Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer
AU - Koh, Stephen Chee Liang
AU - Chan, Yiong Huak
AU - Lutan, Delfi
AU - Marpuang, Johny
AU - Ketut, Suwiyoga
AU - Budiana, Nyoma Gede
AU - Saleh, Agustria Zainu
AU - Aziz, Mohd Farid
AU - Winarto, Hariyono
AU - Pradjatmo, Heru
AU - Hoan, Nguyen Khac Han
AU - Thanh, Pham Viet
AU - Choolani, Mahesh
PY - 2012/6
Y1 - 2012/6
N2 - Objective: To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer. Methods: Serum specimens collected from 5 Indonesian centers and 1 Vietnamese center were analyzed for CA-125, hK6, and hK10 levels. A total of 375 specimens from patients presenting with ovarian tumors, which include 156 benign cysts, 172 epithelial ovarian cancers (stage I/II, n=72; stage III/IV, n=100), 36 germ cell tumors and 11 borderline tumors, were included in the study analysis. Receiver operating characteristic analysis were performed to determine the cutoffs for age, CA-125, hK6, and hK10. Sensitivity, specificity, negative, and positive predictive values were determined for various combinations of the biomarkers. Results: The levels of hK6 and hK10 were significantly elevated in ovarian cancer cases compared to benign cysts. Combination of 3 markers, age/CA-125/hk6 or CA-125/hk6/hk10, showed improved specificity (100%) and positive predictive value (100%) for prediction of ovarian cancer, when compared to the performance of single markers having 80-92% specificity and 74-87% positive predictive value. Four-marker combination, age/CA-125/hK6/hK10 also showed 100% specificity and 100% positive predictive value, although it demonstrated low sensitivity (11.9%) and negative predictive value (52.8%). Conclusion: The combination of human tissue kallikreins and CA-125 showed potential for improving prediction of epithelial ovarian cancer in patients presenting with ovarian tumors.
AB - Objective: To determine the predictive accuracy of the combined panels of serum human tissue kallikreins (hKs) and CA-125 for the detection of epithelial ovarian cancer. Methods: Serum specimens collected from 5 Indonesian centers and 1 Vietnamese center were analyzed for CA-125, hK6, and hK10 levels. A total of 375 specimens from patients presenting with ovarian tumors, which include 156 benign cysts, 172 epithelial ovarian cancers (stage I/II, n=72; stage III/IV, n=100), 36 germ cell tumors and 11 borderline tumors, were included in the study analysis. Receiver operating characteristic analysis were performed to determine the cutoffs for age, CA-125, hK6, and hK10. Sensitivity, specificity, negative, and positive predictive values were determined for various combinations of the biomarkers. Results: The levels of hK6 and hK10 were significantly elevated in ovarian cancer cases compared to benign cysts. Combination of 3 markers, age/CA-125/hk6 or CA-125/hk6/hk10, showed improved specificity (100%) and positive predictive value (100%) for prediction of ovarian cancer, when compared to the performance of single markers having 80-92% specificity and 74-87% positive predictive value. Four-marker combination, age/CA-125/hK6/hK10 also showed 100% specificity and 100% positive predictive value, although it demonstrated low sensitivity (11.9%) and negative predictive value (52.8%). Conclusion: The combination of human tissue kallikreins and CA-125 showed potential for improving prediction of epithelial ovarian cancer in patients presenting with ovarian tumors.
KW - Age
KW - Epithelial ovarian cancer
KW - Tumor markers
UR - http://www.scopus.com/inward/record.url?scp=84863557520&partnerID=8YFLogxK
U2 - 10.3802/jgo.2012.23.3.175
DO - 10.3802/jgo.2012.23.3.175
M3 - Article
C2 - 22808360
AN - SCOPUS:84863557520
SN - 2005-0380
VL - 23
SP - 175
EP - 181
JO - Journal of Gynecologic Oncology
JF - Journal of Gynecologic Oncology
IS - 3
ER -