Combination of varicose vein ligation and non-selective β-blockers as secondary prophylaxis for recurrent bleeding of esophageal varices in liver cirrhosis patient: An evidence-based case report

Aqsha Azhary Nur, Djoko Widodo

Research output: Contribution to journalArticlepeer-review

Abstract

A patient 38 years old diagnosed with hematemesis melena ec recurrent bleeding from esophageal varices and liver cirrhosis. The purpose of this study was to determine whether administration of non-selective β-blockers combine with endoscopy vein ligation will reduce the incidence of recurrent varicose bleeding in liver cirrhosis patient. Literature searching was performed on PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), ProQuest, and EBSCOhost database. Two meta-analysis were obtained. The first meta-analysis study (Funakoshi et al.) shows no significant reduction in the incidence of recurrent esophageal bleeding after administration of the combination therapy (OR = 3.16; 95% CI = 1.76 to 5.34; P <0.0001). From the second meta-analysis (Thiele et al.) reported a decreased risk of recurrent bleeding (RR = 0.65; 95% CI = 0.45 to 0.93; P =0.02). As a conclusion, the combination of a non-selective β-blockers and vein ligation reduce the incidence risk of recurrent esophageal bleeding.

Original languageEnglish
Pages (from-to)6758-6760
Number of pages3
JournalAdvanced Science Letters
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Cirrhosis
  • Esophageal varices
  • Non-selective β-blockers
  • Secondary prophylaxis

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