Combination of alpha-1-acid glycoprotein and alpha-fetoprotein as an improved diagnostic tool for hepatocellular carcinoma

Indra Bachtiar, Julian Mulya Santoso, Benny Atmanegara, Rino Alvani Gani, Irsan Hasan, Laurentius Adrianto Lesmana, Ali Sulaiman, Jianren Gu, Susan Tai

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Background: To evaluate the diagnostic value of α-1-acid glycoprotein (AAG) and the combination with alpha-fetoprotein (AFP) in hepatocellular carcinoma (HCC) patients. Methods: AAG was measured in serum of 65 HCC patients and 54 chronic liver diseases (CLD) patients by using proteomic approach. Sensitivity and specificity of AAG and its combination with AFP were determined and compared with AFP alone for the diagnosis of HCC. Results: The expression concentration of AAG was significantly higher in HCC patients than chronic liver disease with sensitivity (77%) and accuracy (83%). Receiver operating characteristic analysis yielded the following AUC: AFP 0.750 (CI 95% 0.663-0.837), AAG 0.907 (CI 95% 0.855-0.960) and AFP + AAG 0.943 (CI 95% 0.897-0.988). At a specificity of 90%, the combination of AFP + AAG had sensitivity 89% and accuracy 90%, which was higher than sensitivity (52.3%) and accuracy (70%) when using AFP alone. Conclusion: The combination of AAG and AFP shows high sensitivity and improves the accuracy of HCC diagnosis.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalClinica Chimica Acta
Volume399
Issue number1-2
DOIs
Publication statusPublished - Jan 2009

Keywords

  • Hepatocellular carcinoma
  • α-1-acid glycoprotein
  • α-fetoprotein

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