Combination of adipose-derived stem cell conditioned media and minoxidil for hair regrowth in male androgenetic alopecia: a randomized, double-blind clinical trial

Lili Legiawati, Lis Surachmiati Suseno, Irma Bernadette S. Sitohang, Shannaz Nadia Yusharyahya, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Trie Kurniawati, Athaya Ardelia, Kanya Paramastri

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

INTRODUCTION: Treatments for AGA have yet to produce satisfactory outcomes and may cause intolerable side effects. Recent studies have reported that adipose tissue-derived stem cell conditioned media (ADSC-CM) could induce hair growth and regeneration. OBJECTIVE: To investigate the efficacy of ADSC-CM combined with minoxidil for hair regeneration therapy in male AGA. METHODS: This study lasted for 6 weeks. Subjects were divided into two groups: concentrated and non-concentrated ADSC-CM. Scalp was divided vertically in half before intradermal injection was administered from the frontal region of the scalp toward the vertex with a 30G needle, spaced about 1 cm apart. Treatment side received 2 ml of ADSC-CM; the other side was given 2 ml of NaCl 0.9% as placebo. Patients applied 5% minoxidil twice daily post-injection. Improvements were assessed using photographs and trichoscan every 2 weeks. RESULTS: Hair count, hair density, and mean thickness increased significantly on both sides after 6 weeks, while vellus rate decreased proportionally with the increase of terminal rate. No statistically significant differences between treatment groups were found. Minimum side effects were reported, and subjects were satisfied with the results. CONCLUSION: Combination of ADSC-CM and minoxidil could be a potential agent for hair regrowth. Follow-up research with extensive populations, longer duration, and different study design may be required to confirm the exact mechanisms of ADSC-CM on hair growth. TRIAL REGISTRATION: Clinicaltrials.gov, NCT05296863. Registered 25 March 2022-Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT05296863 .

Original languageEnglish
Article number210
Pages (from-to)210
Number of pages1
JournalStem cell research & therapy
Volume14
Issue number1
DOIs
Publication statusPublished - 21 Aug 2023

Keywords

  • Adipose tissue-derived stem cells conditioned media
  • Alopecia
  • Androgenetic alopecia
  • Hair regrowth
  • Minoxidil
  • Stem cells

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