Combination Concentration Effects of Calcium Hydrogenphosphate on Human Enamel Remineralization by Xylitol and Funoran

The combination of xylitol, funoran and calcium hydrogenphosphate have been shown to be effective in enhancing remineralization of human enamel. The aim of this research was to evaluate the effect of calcium hydrogenphosphate concentration combined on remineralization process by xylitol and funoran. Remineralization solutions containing xylitol, funoran, and either four concentrations of calcium hydrogenphosphate were prepared. The initial caries-like enamel lesions were artificially made by demineralizing human enamel slabs in demineralizing solution (pH 4.7) for 3 days. Specimens immersed in the remineralizing solution containing of each concentration of calcium hydrogenphosphate, xylitol, and funoran at 37oC for 2 weeks. The degree of remineralization was evaluated by using Contact Microradiography with a Cu(Kα) x-ray source. Calcium hydrogenphosphate enhanced concentration-dependently the remineralization by xylitol and funoran in human enamel but there was no statistically different between the different concentration of calcium hydrogenphosphate. It was confirmed that calcium hydrogenphosphate tend to enhance concentration-dependently the remineralization by xylitol and funoran. It can be concluded that the combination of xylitol, funoran and calcium hydrogenphosphate in appropriate concentration is effective to enhance remineralization process of initial human enamel caries lesions.