Clustering of allergic outcomes within families and households in areas endemic for helminth infections

Sitti Wahyuni, Erliyani Sartono, Taniawati Supali, Jaring S. Van Der Zee, Andarias Mangali, Ronald Van Ree, Jeanine J. Houwing-Duistermaat, Maria Yazdanbakhsh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Allergy and helminth infections share key immunological features in terms of Th2 responses. Although in industrialized countries clustering of allergic disorders within families has been frequently reported, such information is lacking from areas where helminth infections are endemic. Methods: A total of 466 subjects from 29 families and 112 households participated in this study. Filarial infection, skin test reactivity and IgE to mite as well as total IgE were measured in all samples. Clustering of the allergy-related outcomes due to genetic and household factors was tested. Results: Genetic factors contributed significantly to the clustering of total IgE and allergen-specific IgE, whereas only household factors contributed to the clustering of SPT positivity. Conclusion: Similar to several studies conducted in western populations, total IgE and allergen-specific IgE are influenced by genetic factors in a population resident in a helminth endemic area. However, clustering of SPT positivity due to genetic factors was not significant in the current study raising the question of whether the presence of helminth infections may override genes that are associated with the expression of tissue reactivity to allergens in the west.

Original languageEnglish
Pages (from-to)356-364
Number of pages9
JournalInternational Archives of Allergy and Immunology
Volume136
Issue number4
DOIs
Publication statusPublished - 1 Apr 2005

Keywords

  • Clustering of allergy
  • Helminth
  • IgE
  • Skin prick test

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