TY - JOUR
T1 - Clinicopathology profile evaluated against several risk factors in breast cancer cases
AU - Darwis, Idral
AU - Ramli, Muchlis
AU - Tjindarbumi, Didid
AU - Soetrisno, Esti
AU - Tjahjadi, Gunawan
AU - Hardianto, Endang Sri Roostini
AU - Cornain, Santoso
AU - Harnopidjati, Drupadi
AU - Prihartono, Joedo
AU - Budiningsih, Setyawati
AU - Sakamoto, Goi
AU - Ohno, Yoshiyuki
AU - Wakai, Kenji
N1 - Funding Information:
The authors are grateful to the nurses, Ms. Emi and Ms. Ros and for Public Health Nurses, Ms. July and Ms. Erlaini for excellent care and collection of data of breast cancer cases and controls. We are also indebted to the laboratory technician for excellent work on the surgicopathological specimens. This work was supported by the Ministry of Education, Science, Sports and Culture of Japanese Government, Grants No. 01042007,04042013 and 06042006; and was partly supported by the Indonesian Cancer Foundation. This collaborative study was a part of Special Cancer Research Project in Monbusho International Scientific Research Program, with the approval of the Dean, Faculty of Medicine University of Indonesia, No. 4383/PT02.H4.FK/E/ 88.
Publisher Copyright:
© 1999, Faculty of Medicine, Universitas Indonesia. All rights reserved.
PY - 1999/4/1
Y1 - 1999/4/1
N2 - The second batch case-control study on breast cancer has been conducted as a joint study between Indonesian and Japan. Two hundred and twenty six (226) cases of breast cancer was collected to assess the risk factors and evaluated for their clinical presentation of the disease. The age distribution in some high risk areas showed at age 35 to 55 years, with a single peak between 40 to 50. There was no difference in number of cases in respect to tumor site and menopausal status. The majority of cases 81.6 % were in advanced stage (II1A: 17.7%, 111B: 56.2% and IV: 11.9%) while in contrast stage I and II were very rare (1.3% and 11.9% respectively). Only 75 cases were operable; simple mastectomy was the most frequent surgery carried out (60.0%), followed by modified radical mastectomy (26.7%), classical radical mastectomy (12%) and breast conserving treatment (1.3%). The specimens were reviewed using classification recommended by the Japanese Breast Cancer Society revealed invasive ductal carcinoma (90.4 %) and the special type (9.6 %). Several risk factors were analyzed for their influence to the development of breast cancer, namely: marital status, age at first marriage, menarche, menopausal status, lactation, family history of breast cancer, use of contraceptive and fat consumption. Among the characteristics studied, the following factors significantly increased the risk of breast cancer: menopausal status (RR=1.51; 95% Cl: 1.10-2.09), non-lactating children (RR=1.83; 95% Cl: 1.07-3.11) and fat consumption (RR=2.61; 95% CI: 1.86-3.68), while the use of contraceptive showed protective effect. The findings will be discussed in its benefit relative to both the improvement of the treatment modality and the cancer control program.
AB - The second batch case-control study on breast cancer has been conducted as a joint study between Indonesian and Japan. Two hundred and twenty six (226) cases of breast cancer was collected to assess the risk factors and evaluated for their clinical presentation of the disease. The age distribution in some high risk areas showed at age 35 to 55 years, with a single peak between 40 to 50. There was no difference in number of cases in respect to tumor site and menopausal status. The majority of cases 81.6 % were in advanced stage (II1A: 17.7%, 111B: 56.2% and IV: 11.9%) while in contrast stage I and II were very rare (1.3% and 11.9% respectively). Only 75 cases were operable; simple mastectomy was the most frequent surgery carried out (60.0%), followed by modified radical mastectomy (26.7%), classical radical mastectomy (12%) and breast conserving treatment (1.3%). The specimens were reviewed using classification recommended by the Japanese Breast Cancer Society revealed invasive ductal carcinoma (90.4 %) and the special type (9.6 %). Several risk factors were analyzed for their influence to the development of breast cancer, namely: marital status, age at first marriage, menarche, menopausal status, lactation, family history of breast cancer, use of contraceptive and fat consumption. Among the characteristics studied, the following factors significantly increased the risk of breast cancer: menopausal status (RR=1.51; 95% Cl: 1.10-2.09), non-lactating children (RR=1.83; 95% Cl: 1.07-3.11) and fat consumption (RR=2.61; 95% CI: 1.86-3.68), while the use of contraceptive showed protective effect. The findings will be discussed in its benefit relative to both the improvement of the treatment modality and the cancer control program.
KW - Breast cancer
KW - Case-control study
KW - Clinicopathological
KW - Epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85008678082&partnerID=8YFLogxK
U2 - 10.13181/mji.v8i2.699
DO - 10.13181/mji.v8i2.699
M3 - Article
AN - SCOPUS:85008678082
VL - 8
SP - 123
EP - 127
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
SN - 0853-1773
IS - 2
ER -