Clinical test of chemoradiation compared with radiation response of HPV infection and clinical response in squamous cell carcinoma of the cervix uteri

Objective: To assess the expression of HPV virus which infuenced to the therapy response of squamous cell of cervical cancer.Material and methods: It was an intervention study without control by assessing and comparing the correlation of HPV infection with tumor response to chemoradiation and radiation in squamous cell uterine cervical carcinoma. The design of this study was quasi-experimental research.Results: There were 45 patients which had fulfilled inclusion criteria. Twenty seven patients had chemoradiation and only 28 patients with radiation therapy. From HC-II examination before therapy was given, in chemoradiation group, there were only 1 patient (2.7%) with negative HPV and all patients in radiation group were HPV positive. From chemoradiation group, 8 patients (29.6%) had partial response. It was also found in 7 patients (25%) with radiation. After the therapy, 12 patients (42.9%) had HPV positive in radiation group which compared to chemoradiation group, there were 6 patients (22.2%). From HPV persistence group, there were 4 patients (22.2%) with partial response which compared to 11 patients (29.7%) from HPV negative group after radiation.Conclusion: Chemoradiation tends to influence the persistency of HPV. Chemoradiation group with 22.2% patients have HPV persistent rather than 42.9 % in radiation group and it has statistically unsignificant (P < 0.05). Type of therapy influences to the clinical response. In chemoradiation group, 29.6% patients has partial response, and this response is found in 25% of radiation group. Persistency of HPV is not influenced to clinical response.Keywords: squamous cell of cervical cancer, chemoradiation, radiation, HPV infection.