Abstract
Background: A world-wide pandemic, coronavirus disease 2019 (COVID-19) case was increasing, and so did the mortality rate. By January 10th 2021, there had been 88.387.352 COVID-19 cases with 1.919.204 of them reported deaths. COVID-19 attacks cells containing ACE2+receptors and generates various disorders, especially pneumonia. The condition appears to be worsened by the cytokine storm that caused death. Recently, clinical trials have been carried out to overcome cytokine storms and reduce mortality with umbilical cord derived-mesenchymal stem cells (UC-MSCs). Objective: This study aims to systematically review the literature to better understand the various clinical studies that have been conducted to treat COVID-19 patients with UC-MSCs as adjuvant therapy. Methods: A systematic review of articles published on PubMed, BMC, DOAJ, and Google Scholar platforms was conducted in 2020 with the keyword “MSCs AND Covid-19” and "mesenchymal stem cells AND Covid-19". Obtained data were processed with the PRISMA method. Result: The searching, furthermore, had resulted in 13 genuine articles. The MSCs used included the UC-MSCs with the route of administration, which were generally intravenously. Administration of UC-MSCs could reduce mortality rates, with minimum side effects. Patient demonstrated the decreasing of IL-6, CRP, D-dimer, and TNFαand increased IL-10, CD3+, CD4+, and CD8+. Discussion: UC-MSCs treatment could give positive effects as a therapeutic treatment especially to help COVID 19 patients with moderate to critically severe levels. UC-MSCs have an immunomodulatory effect via its paracrinesecretion mainly to minimize the inflammation reaction rate. Conclusion: The provision of UC-MSCs as a therapy was safe and potentialto be the adjuvant therapyfor the COVID-19 patients
Original language | English |
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Title of host publication | Prosiding KONGRES XV & HUT KE–52 PAAI 2023 -4th LUMMENS: “The Role of Gut-Brain Axis in Indonesian Human Development” |
Publication status | Published - 30 Nov 2023 |
Keywords
- Mesenchymal stem cells
- COVID-19
- therapeutic for COVID-19
- UC-MSCs