Clinical Features of Multisystem Inflammatory Syndrome in Children Associated with COVID-19 in Indonesia

Nina Dwi Putri, Yogi Prawira, Tartila Tartila, Madeleine Ramdhani Jasin, Henny Adriani Puspitasari, Niken Wahyu Puspaningtyas, Wahyuni Indawati, Mulya Rahma Karyanti, Darmawan Budi Setyanto, Ari Prayitno, Irene Yuniar, Fatima Safira Alatas, Eka Laksmi Hidayati, Riski Muhaimin, Titis Prawitasari, Amanda Soebadi, Dina Muktiarti, Fitri Primacakti, Anisa Rahmadhany, Gilbert Sterling OctaviusMulyadi M. Djer, Aryono Hendarto, Rismala Dewi, Nastiti Kaswandani, Antonius Hocky Pudjiadi

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: While the number of cases of multisystem inflammatory syndrome in children (MIS-C) is increasing, reported cases in Asian countries are still low, particularly in Indonesia. This study aimed to describe the characteristics of patients with MIS-C in a tertiary referral hospital in Indonesia. METHODS: This is a cross-sectional study with collected data of patients with MIS-C admitted to Dr. Cipto Mangunkusumo from March 2020 to April 2021. RESULTS: The first case of MIS-C was detected 5 months after the first reported coronavirus disease 2019 case in Indonesia. Thirteen patients out of 158 positive admitted patients for COVID-19 were diagnosed with MIS-C during the study period. Of these 13 patients, 2 patients (15%) had a fatal outcome. Subjects were predominantly male, and the median age was 7.58 years (IQR 12.3) years. Most patients required mechanical ventilation (7 out of 13 patients) and intubation (8 out of 13 patients). Patients who needed intubation usually needed mechanical ventilation. All inflammatory markers, white blood cells, neutrophil counts, and all coagulation factor parameters (except for normal prothrombin time and activated partial prothrombin time) were elevated. The median time to MIS-C diagnosis was 2 days in the survivor group (n = 11) compared to 8.5 days in the non-survivor group (n = 2). Compared to the non-survivor group, those who survived spent more days in the hospital, received vasopressors earlier, and did not require mechanical ventilation as early as the non-survivors. CONCLUSIONS: Our work highlights the differences in MIS-C clinical course, treatment, and clinical outcomes between the two groups.

Original languageEnglish
Article numberfmac025
JournalJournal of Tropical Pediatrics
Volume68
Issue number3
DOIs
Publication statusPublished - 5 Apr 2022

Keywords

  • children
  • COVID-19
  • Indonesia
  • MIS-C

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