Clinical Evaluation of Platelet Rich Plasma Application on Autogenous Bone Graft in a Sheep Model

Vera Julia, Lilies Dwi Sulistyani, Dwi Ariawan, Lully Kurniawan, Arbi Wijaya, Tri Isyani Tungga Dewi, Bambang Pontjo Priosoeryanto, Benny Sjariefsjah Latief

Research output: Contribution to journalArticlepeer-review


Autogenous Bone Graft is considered the safest material due to the compatibility of the material with the patient’s body. A non-vascularized bone graft can apply growth factors such as Plateletrich- plasma (PRP) to catalyze bone healing. In Indonesia, no research currently analyzes PRP's application to autogenous bone grafts in jaw bone in vivo. To analyze the clinical effect of Platelet Rich Plasma (PRP) application in non-vascularized autogenous bone graft in the mandible of Ovis aries sheep as a human model. A total of 24 Ovis aries sheep were classified as PRP and non-PRP groups. A defect on the sheep's mandible measuring 2 cm x 1.5 cm x 2cm was made, and the cut segment was then used as a scaffold. The cut segment was then refined into a mill using pestle and mortar and mixed with Platelet Rich Plasma (PRP). The analyzed variables were signs of infection before and after surgery and signs of inflammation such as wound temperature, hyperemia, and edema. Based on the results of statistical tests, there was no statistically significant difference in temperature, edema, and hyperemia between the PRP and non-PRP groups. Conclusion: PRP applied to mandibular defects does not affect the bone healing mechanism clinically.

Original languageEnglish
Pages (from-to)22-25
Number of pages4
JournalJournal of International Dental and Medical Research
Issue number1
Publication statusPublished - 2024


  • Autogenous bone graft
  • edema
  • hyperemia
  • ovis aries
  • platelet rich plasma
  • temperature


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