TY - JOUR
T1 - Clinical application of mesenchymal stem cell in regenerative medicine
T2 - a narrative review
AU - Margiana, Ria
AU - Markov, Alexander
AU - Zekiy, Angelina O.
AU - Hamza, Mohammed Ubaid
AU - Al-Dabbagh, Khalid A.
AU - Al-Zubaidi, Sura Hasan
AU - Hameed, Noora M.
AU - Ahmad, Irshad
AU - Sivaraman, R.
AU - Kzar, Hamzah H.
AU - Al-Gazally, Moaed E.
AU - Mustafa, Yasser Fakri
AU - Siahmansouri, Homayoon
N1 - Funding Information:
The authors express their gratitude to the Deanship of Scientific Research at King Khalid University for funding this work through the Research Group Program under grant number RGP. 2/122/43.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MSCs can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and hide themselves from the immune system. Certainly, various investigations have revealed anti-inflammatory, anti-aging, reconstruction, and wound healing potentials of MSCs in many in vitro and in vivo models. Moreover, current progresses in the field of MSCs biology have facilitated the progress of particular guidelines and quality control approaches, which eventually lead to clinical application of MSCs. In this literature, we provided a brief overview of immunoregulatory characteristics and immunosuppressive activities of MSCs. In addition, we discussed the enhancement, utilization, and therapeutic responses of MSCs in neural, liver, kidney, bone, heart diseases, and wound healing.
AB - The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide consideration because of their immense potential for immunomodulation and their therapeutic function in tissue regeneration. MSCs can migrate to tissue injury areas to contribute to immune modulation, secrete anti-inflammatory cytokines and hide themselves from the immune system. Certainly, various investigations have revealed anti-inflammatory, anti-aging, reconstruction, and wound healing potentials of MSCs in many in vitro and in vivo models. Moreover, current progresses in the field of MSCs biology have facilitated the progress of particular guidelines and quality control approaches, which eventually lead to clinical application of MSCs. In this literature, we provided a brief overview of immunoregulatory characteristics and immunosuppressive activities of MSCs. In addition, we discussed the enhancement, utilization, and therapeutic responses of MSCs in neural, liver, kidney, bone, heart diseases, and wound healing.
KW - Cell therapy
KW - Mesenchymal stromal cell
KW - Regenerative medicine
KW - Stem cell therapy
KW - Tissue regeneration
UR - http://www.scopus.com/inward/record.url?scp=85135187352&partnerID=8YFLogxK
U2 - 10.1186/s13287-022-03054-0
DO - 10.1186/s13287-022-03054-0
M3 - Review article
AN - SCOPUS:85135187352
SN - 1757-6512
VL - 13
JO - Stem Cell Research and Therapy
JF - Stem Cell Research and Therapy
IS - 1
M1 - 366
ER -