Classification of Foreign Body Reactions due to Industrial Silicone Injection

Ago Harlim, Mpu Kanoko, Siti Aisah

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


METHOD: We modified the classification proposed by Duranti and colleagues, which has categorized a FBR to hyaluronic acid injection into a new classification of an FBR to silicone injection. A cohort study of 31 women suffering from silicone-induced granulomas on their chin was conducted. Granulomatous tissue and submental skin were stained with hematoxylin-eosin and evaluated.

BACKGROUND: A foreign body reaction (FBR) is a typical tissue response to a biomaterial that has been injected or implanted in human body tissue. There has been a lack of data on the classification of foreign body reaction to silicone injection, which can describe the pattern of body tissue responses to silicone.

OBJECTIVE: Determine the foreign body reaction to silicone injection.

RESULTS: Our data revealed that there were at least 7 categories of FBRs to silicone injection that could be developed. Categories 1 to 4 showed inflammatory activity, and categories 5 to 8 showed tissue repair by fibrosis.

CONCLUSION: Using histopathological staining, we are able to sequence the steps of body reactions to silicone injection. Initial inflammatory reaction is then replaced by fibrosis process repairing the damaged tissues. The process depends on the host immune tolerance.

Original languageEnglish
Pages (from-to)1174-1182
Number of pages9
JournalDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
Issue number9
Publication statusPublished - 1 Sept 2018


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