Circulation of various dengue serotypes in a community-based study in Jakarta, Indonesia

Beti Ernawati Dewi, Leonard Nainggolan, Tjahjani Mirawati Sudiro, Settrin Chenderawasi, Patricia Lukas Goentoro, Fithriyah Sjatha

Research output: Contribution to journalArticlepeer-review

Abstract

Dengue virus (DENV) infection remains to be a serious health problem in Indonesia. Community-based dengue studies to determine circulating DENV serotypes based on the geography and season are limited owing to the expensive cost and significant effort required. Many patients with DENV infection are not hospitalized and many visit the hospital in the later phase of the disease. In this study, we performed active DENV surveillance in a community in Jakarta to study the circulating dengue serotypes; adult febrile patients with fever less than 48 hours were recruited. Disease severity was defined using the World Health Organization (WHO) 1997 guidelines. Rapid NS1 dengue antigen detection was used to screen patients with DENV in the community. Viral culture using the C6/36 cell line, an increased antibody titer on hemagglutination inhibition test and enzyme linked immunosorbent assay, or detection of the viral genome on reverse transcription-polymerase chain reaction was used to confirm DENV infection. Of the 102 patients, 68 (66.7%) were confirmed to have DENV infection, with DENV-2 being the most dominant serotype, followed by DENV-3, DENV-1, and DENV-4, in concordance with several reports of mixed DENV infection. Interestingly, in terms of disease severity, although DENV-3 infection was not the predominant circulating serotype, infection with it tended to cause a more severe disease than infection with DENV-2.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalJapanese Journal of Infectious Diseases
Volume74
Issue number1
DOIs
Publication statusPublished - 2021

Fingerprint Dive into the research topics of 'Circulation of various dengue serotypes in a community-based study in Jakarta, Indonesia'. Together they form a unique fingerprint.

Cite this