Níveis circulantes de 25(OH)D3 com fatores de risco de adenoma assintomático e pólipos colorretais proximais sem adenoma

Translated title of the contribution: Circulating level of 25(OH)D3 with risk factors of asymptomatic adenoma and proximal non-adenoma colorectal polyps

Jacobus Albertus, Ignatius Riwanto, Marcellus Simadibrata, Hery D. Purnomo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: An inverse association between circulating vitamin D and adenoma risk has been reported, but less is known about proximal inflammatory-hyperplastic polyps. Purpose: To investigate circulating 25(OH)D3 and risk factors of proximal inflammatory-hyperplastic and adenoma colorectal polyps. Methods: From January 2017 to June 2019, consecutive asymptomatic average-risk participants undergoing initial screening colonoscopy. Questionnaires provided information on colorectal polyp risk factors, and plasma samples were assayed for 25-Hydroxyvitamin-D ‒ 25(OH)D3. The colorectal polyps were assessed, and medical history and demographic data were obtained from each patient. Results: Of the 220 asymptomatic subjects, the prevalence of proximal inflammatory-hyperplastic polyps and adenoma polyps were 16.8%; 18.1% and 22.2%, respectively. Multivariate analysis revealed that low vitamin D (25(OH)D3 < 18 ng/mL, OR = 3.94; 95% CI: 1.81–9.51) and current/former smoking (OR = 6.85; 95% CI: 2.98–15.70), high body mass index (BMI > 24, OR = 5.32, 95% CI: 2.62–4.71) were independent predictors for proximal inflammatory-hyperplastic colorectal polyps (non-adenoma). Low vitamin D (25(OH)D3 < 18 ng/mL, OR = 7.75; 95% CI: 3.19–18.80) and current/former smoking (OR = 3.75; 95% CI: 1.30–10.81), age over 60 years old (OR = 2.38, 95% CI: 1.02–5.57), were independent predictors for adenoma colorectal polyps. Conclusion: Low vitamin D and smoking are common risk factors for both adenomatous and proximal inflammatory hyperplastic polyps. Old age and BMI are additional risk factors for the development of adenomatous and non-adenomatous colorectal polyps.

Translated title of the contributionCirculating level of 25(OH)D3 with risk factors of asymptomatic adenoma and proximal non-adenoma colorectal polyps
Original languagePortuguese
JournalJournal of Coloproctology
DOIs
Publication statusAccepted/In press - 1 Jan 2019

Keywords

  • 25(OH)D3 circulante
  • Adenoma
  • Assintomático
  • Asymptomatic
  • Circulating 25(OH)D
  • Fatores de risco
  • Proximal polyp
  • Pólipo proximal
  • Risk factors

Fingerprint Dive into the research topics of 'Circulating level of 25(OH)D<sub>3</sub> with risk factors of asymptomatic adenoma and proximal non-adenoma colorectal polyps'. Together they form a unique fingerprint.

Cite this