Introduction: Diabetes mellitus may lead to various micro- and macro-vascular complications thus causing significant morbidity, impaired life quality, even mortality. An important goal in the management of diabetes is glycemic control. This can be achieved through several strategies namely lifestyle modifications, pharmacologic treatments, and dietary supplements. In recent studies, cinnamon have been proven to lower blood glucose in diabetic-induced rats and a significant effect on lowering postprandial blood glucose in non-diabetic adults. Aims: To assess the effect of cinnamon supplementation for glycemic control in diabetic patients. Primary endpoints that will be evaluated include HbA1C and fasting plasma glucose (FPG). Method: Electronic literature searching was performed on multiple online searching portals such as PubMed, Cochrane Library, and Google Scholar. Retrieved articles will undergo abstract and full-text screening. Methodological quality of the included studies will be assessed van Tulder et al. criteria for randomized controlled trials. Results: Two studies demonstrated a significant reduction of HbA1C with cinnamon administration in conjunction to conventional oral anti-diabetic therapy. In terms of fasting plasma glucose, one study revealed a lower post-interventional FPGs with cinnamon supplementation while the other did not reveal any statistical significance of 12-weeks cinnamon supplementation to FPGs level. Conclusion: Cinnamon administration of at least 1 gram daily has a lowering effect on HbA1C levels. However, there are still conflicting results regarding the benefit of cinnamon supplementation to the reduction of fasting plasma glucose. Nevertheless, cinnamon supplementation does demonstrate a decreasing trend of FPGs. Application of cinnamon supplementation in daily practice is still doubtful as no standard dosage nor duration of therapy is yet to be established. Further investigation regarding standard therapeutic dose of cinnamon supplementation with a longer duration of follow-up are warranted.
- Plasma Glucose
- Type 2 Diabetes Mellitus