Cinnamic acid derivatives as α-glucosidase inhibitor agents

Teni Ernawati, Maksum Radji, Muhammad Hanafi, Abdul Mun'im, Arry Yanuar

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the substitution of the phenyl group, second is the additive reaction into the α-β unsaturated, and third is the chemical reaction with carboxylic acid functional groups. The synthesis and modification of the structure of cinnamic acid are very influential in inhibitory activity against α-glucosidase.

Original languageEnglish
Pages (from-to)151-160
Number of pages10
JournalIndonesian Journal of Chemistry
Volume17
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Antidiabetic
  • Cinnamic acid derivative
  • Natural products
  • Synthesis
  • α-glucosidase inhibitor

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