Abstract
This paper reviews biological activity of some cinnamic acid derivative compounds which are isolated from natural materials and synthesized from the chemical compounds as an agent of α-glucosidase inhibitors for the antidiabetic drug. Aegeline, anhydroaegeline and aeglinoside B are natural products isolated compounds that have potential as an α-glucosidase inhibitor. Meanwhile, α-glucosidase inhibitor class of derivatives of cinnamic acid synthesized compounds are p-methoxy cinnamic acid and p-methoxyethyl cinnamate. Chemically, cinnamic acid has three main functional groups: first is the substitution of the phenyl group, second is the additive reaction into the α-β unsaturated, and third is the chemical reaction with carboxylic acid functional groups. The synthesis and modification of the structure of cinnamic acid are very influential in inhibitory activity against α-glucosidase.
Original language | English |
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Pages (from-to) | 151-160 |
Number of pages | 10 |
Journal | Indonesian Journal of Chemistry |
Volume | 17 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Antidiabetic
- Cinnamic acid derivative
- Natural products
- Synthesis
- α-glucosidase inhibitor