Chronic suppurative otitis media and immunocompromised status in paediatric patients

Ratna Dwi Restuti, Ayu Astria Sriyana, Harim Priyono, Rangga Rayendra Saleh, Tri Juda Airlangga, Semiramis Zizlavsky, Ronny Suwento, Fikry Hamdan Yasin

Research output: Contribution to journalArticlepeer-review


Introduction: The role of immunodeficiency in the development of chronic suppurative otitis media (CSOM), especially in paediatric populations, have yet to be fully elucidated. The purposesof this study is to investigate the association between immunocompromised status and CSOM among paediatric population in a tertiary hospital in Indonesia. Materials and Methods: A cross-sectional study was performed by retrieving medical records of paediatric patients, with and without CSOM (age 0–18 years), visiting otorhinolaryngology (ENT-HNS) outpatient clinic in a tertiary hospital in Indonesia (2018-2020). We collected data on comorbidities causing immunosuppression such as HIV status, tuberculosis, and cancer. Results: Among the 1018 included patients (50 immunocompromised children), HIV infection was the most common cause of immunodeficiency in the CSOM group (24 patients, 60%), and cancer in the non-CSOM group (10 patients, 100%). We found a significant association between immunocompromised hosts and CSOM (odds ratio 19.5 [95% confidence interval: 9.5–39.9], p<0.001). Conclusion: Immunocompromised children with HIV, tuberculosis, or cancer may be more vulnerable to CSOM. Further research is required to explore the association between other immunocompromised conditions and CSOM in paediatric populations.

Original languageEnglish
Pages (from-to)619-621
Number of pages3
JournalMedical Journal of Malaysia
Issue number5
Publication statusPublished - Sep 2022


  • Chronic suppurative otitis media
  • HIV
  • immunocompromised host
  • paediatrics
  • tuberculosis


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