TY - JOUR
T1 - Chronic suppurative otitis media and immunocompromised status in paediatric patients
AU - Restuti, Ratna Dwi
AU - Sriyana, Ayu Astria
AU - Priyono, Harim
AU - Saleh, Rangga Rayendra
AU - Airlangga, Tri Juda
AU - Zizlavsky, Semiramis
AU - Suwento, Ronny
AU - Yasin, Fikry Hamdan
N1 - Publisher Copyright:
© 2022, Malaysian Medical Association. All rights reserved.
PY - 2022/9
Y1 - 2022/9
N2 - Introduction: The role of immunodeficiency in the development of chronic suppurative otitis media (CSOM), especially in paediatric populations, have yet to be fully elucidated. The purposesof this study is to investigate the association between immunocompromised status and CSOM among paediatric population in a tertiary hospital in Indonesia. Materials and Methods: A cross-sectional study was performed by retrieving medical records of paediatric patients, with and without CSOM (age 0–18 years), visiting otorhinolaryngology (ENT-HNS) outpatient clinic in a tertiary hospital in Indonesia (2018-2020). We collected data on comorbidities causing immunosuppression such as HIV status, tuberculosis, and cancer. Results: Among the 1018 included patients (50 immunocompromised children), HIV infection was the most common cause of immunodeficiency in the CSOM group (24 patients, 60%), and cancer in the non-CSOM group (10 patients, 100%). We found a significant association between immunocompromised hosts and CSOM (odds ratio 19.5 [95% confidence interval: 9.5–39.9], p<0.001). Conclusion: Immunocompromised children with HIV, tuberculosis, or cancer may be more vulnerable to CSOM. Further research is required to explore the association between other immunocompromised conditions and CSOM in paediatric populations.
AB - Introduction: The role of immunodeficiency in the development of chronic suppurative otitis media (CSOM), especially in paediatric populations, have yet to be fully elucidated. The purposesof this study is to investigate the association between immunocompromised status and CSOM among paediatric population in a tertiary hospital in Indonesia. Materials and Methods: A cross-sectional study was performed by retrieving medical records of paediatric patients, with and without CSOM (age 0–18 years), visiting otorhinolaryngology (ENT-HNS) outpatient clinic in a tertiary hospital in Indonesia (2018-2020). We collected data on comorbidities causing immunosuppression such as HIV status, tuberculosis, and cancer. Results: Among the 1018 included patients (50 immunocompromised children), HIV infection was the most common cause of immunodeficiency in the CSOM group (24 patients, 60%), and cancer in the non-CSOM group (10 patients, 100%). We found a significant association between immunocompromised hosts and CSOM (odds ratio 19.5 [95% confidence interval: 9.5–39.9], p<0.001). Conclusion: Immunocompromised children with HIV, tuberculosis, or cancer may be more vulnerable to CSOM. Further research is required to explore the association between other immunocompromised conditions and CSOM in paediatric populations.
KW - Chronic suppurative otitis media
KW - HIV
KW - immunocompromised host
KW - paediatrics
KW - tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85138935136&partnerID=8YFLogxK
M3 - Article
C2 - 36169076
AN - SCOPUS:85138935136
SN - 0300-5283
VL - 77
SP - 619
EP - 621
JO - Medical Journal of Malaysia
JF - Medical Journal of Malaysia
IS - 5
ER -