Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia

N. Durier; Evy Yunihastuti; K. Ruxrungtham; N. V. Kinh; A. Kamarulzaman; D. Boettiger; Alvina Widhani; A. Avihingsanon; B. V. Huy; S. F.B. Syed Omar; A. Sanityoso; S. Chittmittrapap; N. T.H. Dung; V. Pillai; T. Suwan-Ampai; M. Law; A. H. Sohn; G. Matthews

doi:10.1111/jvh.12630

Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia

N. Durier, Evy Yunihastuti, K. Ruxrungtham, N. V. Kinh, A. Kamarulzaman, D. Boettiger, Alvina Widhani, A. Avihingsanon, B. V. Huy, S. F.B. Syed Omar, A. Sanityoso, S. Chittmittrapap, N. T.H. Dung, V. Pillai, T. Suwan-Ampai, M. Law, A. H. Sohn, G. Matthews

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Data on markers of hepatitis C virus (HCV) disease in HIV-HCV-coinfected patients in resource-limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan^®) in 480 HIV-infected patients with positive HCV antibody in four HIV treatment centres in South-East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7-42.5) years, 365 (76.0%) reported HCV exposure through injecting drug use, and 453 (94.4%) were on combination antiretroviral therapy. The median (IQR) CD4 count was 446 (325-614) cells/mm³ and 208 (94.1%) of 221 patients tested had HIV-1 RNA <400 copies/mL. A total of 412 (85.8%) had detectable HCV RNA, at a median (IQR) of 6.2 (5.4-6.6) log₁₀ IU/mL. Among 380 patients with HCV GT, 223 (58.7%) had GT1, 97 (25.5%) had GT3, 43 (11.3%) had GT6, eight (2.1%) had GT4, two (0.5%) had GT2, and seven (1.8%) had indeterminate GT. Of 222 patients with IL28B testing, 189 (85.1%) had rs12979860 CC genotype, and 199 (89.6%) had rs8099917 TT genotype. Of 380 patients with FibroScan^®, 143 (37.6%) had no/mild liver fibrosis (F0-F1), 83 (21.8%) had moderate fibrosis (F2), 74 (19.5%) had severe fibrosis (F3), and 79 (20.8%) had cirrhosis (F4). One patient (0.3%) had FibroScan^® failure. In conclusion, a high proportion of HIV-HCV-coinfected patients had chronic HCV infection. HCV GT1 was predominant, and 62% of patients had liver disease warranting prompt treatment (≥F2).

Original language	English
Pages (from-to)	187-196
Number of pages	10
Journal	Journal of Viral Hepatitis
Volume	24
Issue number	3
DOIs	https://doi.org/10.1111/jvh.12630
Publication status	Published - 1 Mar 2017

Keywords

Asia
HIV
chronic infection
fibrosis
hepatitis C virus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jvh.12630

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Durier, N., Yunihastuti, E., Ruxrungtham, K., Kinh, N. V., Kamarulzaman, A., Boettiger, D., Widhani, A., Avihingsanon, A., Huy, B. V., Syed Omar, S. F. B., Sanityoso, A., Chittmittrapap, S., Dung, N. T. H., Pillai, V., Suwan-Ampai, T., Law, M., Sohn, A. H., & Matthews, G. (2017). Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia. Journal of Viral Hepatitis, 24(3), 187-196. https://doi.org/10.1111/jvh.12630

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title = "Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia",

abstract = "Data on markers of hepatitis C virus (HCV) disease in HIV-HCV-coinfected patients in resource-limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan{\textregistered}) in 480 HIV-infected patients with positive HCV antibody in four HIV treatment centres in South-East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7-42.5) years, 365 (76.0%) reported HCV exposure through injecting drug use, and 453 (94.4%) were on combination antiretroviral therapy. The median (IQR) CD4 count was 446 (325-614) cells/mm3 and 208 (94.1%) of 221 patients tested had HIV-1 RNA <400 copies/mL. A total of 412 (85.8%) had detectable HCV RNA, at a median (IQR) of 6.2 (5.4-6.6) log10 IU/mL. Among 380 patients with HCV GT, 223 (58.7%) had GT1, 97 (25.5%) had GT3, 43 (11.3%) had GT6, eight (2.1%) had GT4, two (0.5%) had GT2, and seven (1.8%) had indeterminate GT. Of 222 patients with IL28B testing, 189 (85.1%) had rs12979860 CC genotype, and 199 (89.6%) had rs8099917 TT genotype. Of 380 patients with FibroScan{\textregistered}, 143 (37.6%) had no/mild liver fibrosis (F0-F1), 83 (21.8%) had moderate fibrosis (F2), 74 (19.5%) had severe fibrosis (F3), and 79 (20.8%) had cirrhosis (F4). One patient (0.3%) had FibroScan{\textregistered} failure. In conclusion, a high proportion of HIV-HCV-coinfected patients had chronic HCV infection. HCV GT1 was predominant, and 62% of patients had liver disease warranting prompt treatment (≥F2).",

keywords = "Asia, HIV, chronic infection, fibrosis, hepatitis C virus",

author = "N. Durier and Evy Yunihastuti and K. Ruxrungtham and Kinh, {N. V.} and A. Kamarulzaman and D. Boettiger and Alvina Widhani and A. Avihingsanon and Huy, {B. V.} and {Syed Omar}, {S. F.B.} and A. Sanityoso and S. Chittmittrapap and Dung, {N. T.H.} and V. Pillai and T. Suwan-Ampai and M. Law and Sohn, {A. H.} and G. Matthews",

note = "Publisher Copyright: {\textcopyright} 2016 John Wiley & Sons Ltd",

year = "2017",

month = mar,

day = "1",

doi = "10.1111/jvh.12630",

language = "English",

volume = "24",

pages = "187--196",

journal = "Journal of Viral Hepatitis",

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Durier, N, Yunihastuti, E, Ruxrungtham, K, Kinh, NV, Kamarulzaman, A, Boettiger, D, Widhani, A, Avihingsanon, A, Huy, BV, Syed Omar, SFB, Sanityoso, A, Chittmittrapap, S, Dung, NTH, Pillai, V, Suwan-Ampai, T, Law, M, Sohn, AH & Matthews, G 2017, 'Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia', Journal of Viral Hepatitis, vol. 24, no. 3, pp. 187-196. https://doi.org/10.1111/jvh.12630

TY - JOUR

T1 - Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia

AU - Durier, N.

AU - Yunihastuti, Evy

AU - Ruxrungtham, K.

AU - Kinh, N. V.

AU - Kamarulzaman, A.

AU - Boettiger, D.

AU - Widhani, Alvina

AU - Avihingsanon, A.

AU - Huy, B. V.

AU - Syed Omar, S. F.B.

AU - Sanityoso, A.

AU - Chittmittrapap, S.

AU - Dung, N. T.H.

AU - Pillai, V.

AU - Suwan-Ampai, T.

AU - Law, M.

AU - Sohn, A. H.

AU - Matthews, G.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Data on markers of hepatitis C virus (HCV) disease in HIV-HCV-coinfected patients in resource-limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan®) in 480 HIV-infected patients with positive HCV antibody in four HIV treatment centres in South-East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7-42.5) years, 365 (76.0%) reported HCV exposure through injecting drug use, and 453 (94.4%) were on combination antiretroviral therapy. The median (IQR) CD4 count was 446 (325-614) cells/mm3 and 208 (94.1%) of 221 patients tested had HIV-1 RNA <400 copies/mL. A total of 412 (85.8%) had detectable HCV RNA, at a median (IQR) of 6.2 (5.4-6.6) log10 IU/mL. Among 380 patients with HCV GT, 223 (58.7%) had GT1, 97 (25.5%) had GT3, 43 (11.3%) had GT6, eight (2.1%) had GT4, two (0.5%) had GT2, and seven (1.8%) had indeterminate GT. Of 222 patients with IL28B testing, 189 (85.1%) had rs12979860 CC genotype, and 199 (89.6%) had rs8099917 TT genotype. Of 380 patients with FibroScan®, 143 (37.6%) had no/mild liver fibrosis (F0-F1), 83 (21.8%) had moderate fibrosis (F2), 74 (19.5%) had severe fibrosis (F3), and 79 (20.8%) had cirrhosis (F4). One patient (0.3%) had FibroScan® failure. In conclusion, a high proportion of HIV-HCV-coinfected patients had chronic HCV infection. HCV GT1 was predominant, and 62% of patients had liver disease warranting prompt treatment (≥F2).

AB - Data on markers of hepatitis C virus (HCV) disease in HIV-HCV-coinfected patients in resource-limited settings are scarce. We assessed HCV RNA, HCV genotype (GT), IL28B GT and liver fibrosis (FibroScan®) in 480 HIV-infected patients with positive HCV antibody in four HIV treatment centres in South-East Asia. We enrolled 165 (34.4%) patients in Jakarta, 158 (32.9%) in Bangkok, 110 (22.9%) in Hanoi and 47 (9.8%) in Kuala Lumpur. Overall, 426 (88.8%) were male, the median (IQR) age was 38.1 (34.7-42.5) years, 365 (76.0%) reported HCV exposure through injecting drug use, and 453 (94.4%) were on combination antiretroviral therapy. The median (IQR) CD4 count was 446 (325-614) cells/mm3 and 208 (94.1%) of 221 patients tested had HIV-1 RNA <400 copies/mL. A total of 412 (85.8%) had detectable HCV RNA, at a median (IQR) of 6.2 (5.4-6.6) log10 IU/mL. Among 380 patients with HCV GT, 223 (58.7%) had GT1, 97 (25.5%) had GT3, 43 (11.3%) had GT6, eight (2.1%) had GT4, two (0.5%) had GT2, and seven (1.8%) had indeterminate GT. Of 222 patients with IL28B testing, 189 (85.1%) had rs12979860 CC genotype, and 199 (89.6%) had rs8099917 TT genotype. Of 380 patients with FibroScan®, 143 (37.6%) had no/mild liver fibrosis (F0-F1), 83 (21.8%) had moderate fibrosis (F2), 74 (19.5%) had severe fibrosis (F3), and 79 (20.8%) had cirrhosis (F4). One patient (0.3%) had FibroScan® failure. In conclusion, a high proportion of HIV-HCV-coinfected patients had chronic HCV infection. HCV GT1 was predominant, and 62% of patients had liver disease warranting prompt treatment (≥F2).

KW - Asia

KW - HIV

KW - chronic infection

KW - fibrosis

KW - hepatitis C virus

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U2 - 10.1111/jvh.12630

DO - 10.1111/jvh.12630

M3 - Article

C2 - 27917597

AN - SCOPUS:85006415465

SN - 1352-0504

VL - 24

SP - 187

EP - 196

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

IS - 3

ER -

Chronic hepatitis C infection and liver disease in HIV-coinfected patients in Asia

Abstract

Keywords

UN SDGs

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