Chronic complications risk among type 2 diabetes patients with a family history of diabetes

Dicky l. Tahapary; Syahidatul Wafa; Christian Tricaesario; Felix f. Widjaja; Jimmy Tandradynata; Rudy Kurniawan; William Djauhari; Afif h. Maruf; Muhammad Yamin; Sidartawan Soegondo

doi:10.1002/cdt3.80

Chronic complications risk among type 2 diabetes patients with a family history of diabetes

Dicky l. Tahapary, Syahidatul Wafa, Christian Tricaesario, Felix f. Widjaja, Jimmy Tandradynata, Rudy Kurniawan, William Djauhari, Afif h. Maruf, Muhammad Yamin, Sidartawan Soegondo

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Family history of diabetes (FH+) has been associated with early metabolic alteration including insulin resistance,
lipid metabolism, and ectopic fat accumulation even in healthy individuals.1–3 Furthermore, normoglycemic firstdegree relatives of type 2 diabetes mellitus (T2DM)
have been documented having increased carotid intimamedia
thickness and pro‐inflammatory cytokines.4,5 Taken together, individuals with FH+, who were otherwise healthy, have shown to possess susceptibility for diabetes
mellitus (DM) chronic complication. Hence, this study aimed to investigate whether FH+ increased the risk of
chronic complications in patients with overt T2DM. This was a cross‐sectional study which included adult patients with T2DM visiting a private hospital
integrated diabetes center in South Tangerang (urban area outskirt of Jakarta), Indonesia from December 2020 to November 2021. Those without any documented blood test results were excluded. FH+ was defined as having first‐ and/or second‐degree relatives with T2DM.

Original language	English
Journal	Chronic Diseases and Translational Medicine
DOIs	https://doi.org/10.1002/cdt3.80
Publication status	Published - 2023

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Cite this

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title = "Chronic complications risk among type 2 diabetes patients with a family history of diabetes",

abstract = "Family history of diabetes (FH+) has been associated with early metabolic alteration including insulin resistance,lipid metabolism, and ectopic fat accumulation even in healthy individuals.1–3 Furthermore, normoglycemic firstdegree relatives of type 2 diabetes mellitus (T2DM)have been documented having increased carotid intimamediathickness and pro‐inflammatory cytokines.4,5 Taken together, individuals with FH+, who were otherwise healthy, have shown to possess susceptibility for diabetesmellitus (DM) chronic complication. Hence, this study aimed to investigate whether FH+ increased the risk ofchronic complications in patients with overt T2DM. This was a cross‐sectional study which included adult patients with T2DM visiting a private hospitalintegrated diabetes center in South Tangerang (urban area outskirt of Jakarta), Indonesia from December 2020 to November 2021. Those without any documented blood test results were excluded. FH+ was defined as having first‐ and/or second‐degree relatives with T2DM.",

author = "Tahapary, {Dicky l.} and Syahidatul Wafa and Christian Tricaesario and Widjaja, {Felix f.} and Jimmy Tandradynata and Rudy Kurniawan and William Djauhari and Maruf, {Afif h.} and Muhammad Yamin and Sidartawan Soegondo",

year = "2023",

doi = "10.1002/cdt3.80",

language = "English",

journal = "Chronic Diseases and Translational Medicine",

issn = "2589-0514",

}

TY - JOUR

T1 - Chronic complications risk among type 2 diabetes patients with a family history of diabetes

AU - Tahapary, Dicky l.

AU - Wafa, Syahidatul

AU - Tricaesario, Christian

AU - Widjaja, Felix f.

AU - Tandradynata, Jimmy

AU - Kurniawan, Rudy

AU - Djauhari, William

AU - Maruf, Afif h.

AU - Yamin, Muhammad

AU - Soegondo, Sidartawan

PY - 2023

Y1 - 2023

N2 - Family history of diabetes (FH+) has been associated with early metabolic alteration including insulin resistance,lipid metabolism, and ectopic fat accumulation even in healthy individuals.1–3 Furthermore, normoglycemic firstdegree relatives of type 2 diabetes mellitus (T2DM)have been documented having increased carotid intimamediathickness and pro‐inflammatory cytokines.4,5 Taken together, individuals with FH+, who were otherwise healthy, have shown to possess susceptibility for diabetesmellitus (DM) chronic complication. Hence, this study aimed to investigate whether FH+ increased the risk ofchronic complications in patients with overt T2DM. This was a cross‐sectional study which included adult patients with T2DM visiting a private hospitalintegrated diabetes center in South Tangerang (urban area outskirt of Jakarta), Indonesia from December 2020 to November 2021. Those without any documented blood test results were excluded. FH+ was defined as having first‐ and/or second‐degree relatives with T2DM.

AB - Family history of diabetes (FH+) has been associated with early metabolic alteration including insulin resistance,lipid metabolism, and ectopic fat accumulation even in healthy individuals.1–3 Furthermore, normoglycemic firstdegree relatives of type 2 diabetes mellitus (T2DM)have been documented having increased carotid intimamediathickness and pro‐inflammatory cytokines.4,5 Taken together, individuals with FH+, who were otherwise healthy, have shown to possess susceptibility for diabetesmellitus (DM) chronic complication. Hence, this study aimed to investigate whether FH+ increased the risk ofchronic complications in patients with overt T2DM. This was a cross‐sectional study which included adult patients with T2DM visiting a private hospitalintegrated diabetes center in South Tangerang (urban area outskirt of Jakarta), Indonesia from December 2020 to November 2021. Those without any documented blood test results were excluded. FH+ was defined as having first‐ and/or second‐degree relatives with T2DM.

U2 - 10.1002/cdt3.80

DO - 10.1002/cdt3.80

M3 - Article

SN - 2589-0514

JO - Chronic Diseases and Translational Medicine

JF - Chronic Diseases and Translational Medicine

ER -

Chronic complications risk among type 2 diabetes patients with a family history of diabetes

Abstract

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