Chronic complications risk among type 2 diabetes patients with a family history of diabetes

Dicky l. Tahapary, Syahidatul Wafa, Christian Tricaesario, Felix f. Widjaja, Jimmy Tandradynata, Rudy Kurniawan, William Djauhari, Afif h. Maruf, Muhammad Yamin, Sidartawan Soegondo

Research output: Contribution to journalArticlepeer-review


Family history of diabetes (FH+) has been associated with early metabolic alteration including insulin resistance,
lipid metabolism, and ectopic fat accumulation even in healthy individuals.1–3 Furthermore, normoglycemic firstdegree relatives of type 2 diabetes mellitus (T2DM)
have been documented having increased carotid intimamedia
thickness and pro‐inflammatory cytokines.4,5 Taken together, individuals with FH+, who were otherwise healthy, have shown to possess susceptibility for diabetes
mellitus (DM) chronic complication. Hence, this study aimed to investigate whether FH+ increased the risk of
chronic complications in patients with overt T2DM. This was a cross‐sectional study which included adult patients with T2DM visiting a private hospital
integrated diabetes center in South Tangerang (urban area outskirt of Jakarta), Indonesia from December 2020 to November 2021. Those without any documented blood test results were excluded. FH+ was defined as having first‐ and/or second‐degree relatives with T2DM.
Original languageEnglish
JournalChronic Diseases and Translational Medicine
Publication statusPublished - 2023


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