Cholesterol-lowering effects of extract from Garcinia daedalanthera in hyperlipidemic rats

Sarah Zielda Najib, Wilzar Fachri, Rani Sauriasari, Berna Elya, Raymond Tjandrawinata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: A native plant from Indonesia, Garcinia daedalanthera has been scientifically proven have antidiabetic effects and antioxidant activity. We hypothesized that Garcinia daedalanthera can modulate the lipid profiles of hyperlipidemic rats. Objective: This study aimed to evaluate the antihyperlipidemic potential of Garcinia daedalanthera extract. Materials and Methods: Garcinia daedalanthera leaves extract (GDE) were orally administrated to high fat diet-induced rats for 15 days. After the end of experimental period (43 days) the lipid profiles were estimated along with histopathological liver examination of animals. Results: The results showed that Garcinia daedalanthera extract significantly reduced the level of serum total cholesterol, total triglycerides and low-density lipoprotein as compared to control group with an increasing level of serum high-density lipoprotein. Furthermore, the extract has a favorable effect on histopathological study. Conclusion: This study proved antilipidemic property by lowering altered levels of lipid profile in male wistar rats and suggest lipid lowering effects of Garcinia daedalanthera extract which serves as a new potential natural product for preventing hyperlipidemia.

Original languageEnglish
Pages (from-to)1125-1128
Number of pages4
JournalPharmacognosy Journal
Volume10
Issue number6
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • Anti-cholesterol
  • Garcinia
  • Herbal
  • In vivo
  • Pre-clinical study
  • Rat

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