Abstract
Background: A native plant from Indonesia, Garcinia daedalanthera has been scientifically proven have antidiabetic effects and antioxidant activity. We hypothesized that Garcinia daedalanthera can modulate the lipid profiles of hyperlipidemic rats. Objective: This study aimed to evaluate the antihyperlipidemic potential of Garcinia daedalanthera extract. Materials and Methods: Garcinia daedalanthera leaves extract (GDE) were orally administrated to high fat diet-induced rats for 15 days. After the end of experimental period (43 days) the lipid profiles were estimated along with histopathological liver examination of animals. Results: The results showed that Garcinia daedalanthera extract significantly reduced the level of serum total cholesterol, total triglycerides and low-density lipoprotein as compared to control group with an increasing level of serum high-density lipoprotein. Furthermore, the extract has a favorable effect on histopathological study. Conclusion: This study proved antilipidemic property by lowering altered levels of lipid profile in male wistar rats and suggest lipid lowering effects of Garcinia daedalanthera extract which serves as a new potential natural product for preventing hyperlipidemia.
| Original language | English |
|---|---|
| Pages (from-to) | 1125-1128 |
| Number of pages | 4 |
| Journal | Pharmacognosy Journal |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Nov 2018 |
Keywords
- Anti-cholesterol
- Garcinia
- Herbal
- In vivo
- Pre-clinical study
- Rat