Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system

S. Astuti; Y. Yulizar; A. Saefumillah; D. O.B. Apriandanu

doi:10.1063/5.0007925

Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system

Department of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Citations (Scopus)

Abstract

Lamivudine is an antiretroviral (ARV) drug from category of nucleoside reverse transcriptase inhibitors (NRTI) for both the human immunodeficiency virus (HIV) and hepatitis B treatments. Besides, chitosan in nanoparticles is used as a matrix in good drug delivery systems for both hydrophobic and hydrophilic ARV drugs. Chitosan modification has been widely investigated to enhance its hydrophilicity properties to bind lamivudine. This study aims to modify chitosan nanoparticles (CSNP) using polyethylene glycol as a drug delivery system for lamivudine. CSNP was modified by polyethylene glycol, then loaded with lamivudine and crosslinked by sodium tri polyphosphate (TPP) to produce lamivudine nanodrug in a chitosan drug delivery system. According to the particle size analyzer (PSA), nanodrug has particle size approximately 79.25 nm. The encapsulation efficiency of nanodrug is 86.96 % from 28.98 % loading concentration. The drug release tests of lamivudine in phosphate buffer at pH of 3.0 for 4 h; pH of 6.8 and 7.4 for 24 h were 72.37; 84.96 and 80.40 % respectively.

Original language	English
Title of host publication	Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
Editors	Terry Mart, Djoko Triyono, Tribidasari Anggraningrum Ivandini
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735420014
DOIs	https://doi.org/10.1063/5.0007925
Publication status	Published - 1 Jun 2020
Event	5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 - Depok, Indonesia Duration: 9 Jul 2019 → 10 Jul 2019

Publication series

Name	AIP Conference Proceedings
Volume	2242
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
Country/Territory	Indonesia
City	Depok
Period	9/07/19 → 10/07/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Lamivudine
antiretroviral
chitosan nanoparticle
nanodrug

Access to Document

10.1063/5.0007925

Cite this

Astuti, S., Yulizar, Y., Saefumillah, A., & Apriandanu, D. O. B. (2020). Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system. In T. Mart, D. Triyono, & T. A. Ivandini (Eds.), Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 Article 040029 (AIP Conference Proceedings; Vol. 2242). American Institute of Physics Inc.. https://doi.org/10.1063/5.0007925

Astuti, S. ; Yulizar, Y. ; Saefumillah, A. et al. / Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system. Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019. editor / Terry Mart ; Djoko Triyono ; Tribidasari Anggraningrum Ivandini. American Institute of Physics Inc., 2020. (AIP Conference Proceedings).

@inproceedings{3a975719cacf467191bd727d0b55a632,

title = "Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system",

abstract = "Lamivudine is an antiretroviral (ARV) drug from category of nucleoside reverse transcriptase inhibitors (NRTI) for both the human immunodeficiency virus (HIV) and hepatitis B treatments. Besides, chitosan in nanoparticles is used as a matrix in good drug delivery systems for both hydrophobic and hydrophilic ARV drugs. Chitosan modification has been widely investigated to enhance its hydrophilicity properties to bind lamivudine. This study aims to modify chitosan nanoparticles (CSNP) using polyethylene glycol as a drug delivery system for lamivudine. CSNP was modified by polyethylene glycol, then loaded with lamivudine and crosslinked by sodium tri polyphosphate (TPP) to produce lamivudine nanodrug in a chitosan drug delivery system. According to the particle size analyzer (PSA), nanodrug has particle size approximately 79.25 nm. The encapsulation efficiency of nanodrug is 86.96 \% from 28.98 \% loading concentration. The drug release tests of lamivudine in phosphate buffer at pH of 3.0 for 4 h; pH of 6.8 and 7.4 for 24 h were 72.37; 84.96 and 80.40 \% respectively.",

keywords = "Lamivudine, antiretroviral, chitosan nanoparticle, nanodrug",

author = "S. Astuti and Y. Yulizar and A. Saefumillah and Apriandanu, \{D. O.B.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Author(s).; 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 ; Conference date: 09-07-2019 Through 10-07-2019",

year = "2020",

month = jun,

day = "1",

doi = "10.1063/5.0007925",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Terry Mart and Djoko Triyono and Ivandini, \{Tribidasari Anggraningrum\}",

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address = "United States",

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Astuti, S, Yulizar, Y , Saefumillah, A & Apriandanu, DOB 2020, Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system. in T Mart, D Triyono & TA Ivandini (eds), Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019., 040029, AIP Conference Proceedings, vol. 2242, American Institute of Physics Inc., 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019, Depok, Indonesia, 9/07/19. https://doi.org/10.1063/5.0007925

Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system. / Astuti, S.; Yulizar, Y.; Saefumillah, A. et al.
Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019. ed. / Terry Mart; Djoko Triyono; Tribidasari Anggraningrum Ivandini. American Institute of Physics Inc., 2020. 040029 (AIP Conference Proceedings; Vol. 2242).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system

AU - Astuti, S.

AU - Yulizar, Y.

AU - Saefumillah, A.

AU - Apriandanu, D. O.B.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Lamivudine is an antiretroviral (ARV) drug from category of nucleoside reverse transcriptase inhibitors (NRTI) for both the human immunodeficiency virus (HIV) and hepatitis B treatments. Besides, chitosan in nanoparticles is used as a matrix in good drug delivery systems for both hydrophobic and hydrophilic ARV drugs. Chitosan modification has been widely investigated to enhance its hydrophilicity properties to bind lamivudine. This study aims to modify chitosan nanoparticles (CSNP) using polyethylene glycol as a drug delivery system for lamivudine. CSNP was modified by polyethylene glycol, then loaded with lamivudine and crosslinked by sodium tri polyphosphate (TPP) to produce lamivudine nanodrug in a chitosan drug delivery system. According to the particle size analyzer (PSA), nanodrug has particle size approximately 79.25 nm. The encapsulation efficiency of nanodrug is 86.96 % from 28.98 % loading concentration. The drug release tests of lamivudine in phosphate buffer at pH of 3.0 for 4 h; pH of 6.8 and 7.4 for 24 h were 72.37; 84.96 and 80.40 % respectively.

AB - Lamivudine is an antiretroviral (ARV) drug from category of nucleoside reverse transcriptase inhibitors (NRTI) for both the human immunodeficiency virus (HIV) and hepatitis B treatments. Besides, chitosan in nanoparticles is used as a matrix in good drug delivery systems for both hydrophobic and hydrophilic ARV drugs. Chitosan modification has been widely investigated to enhance its hydrophilicity properties to bind lamivudine. This study aims to modify chitosan nanoparticles (CSNP) using polyethylene glycol as a drug delivery system for lamivudine. CSNP was modified by polyethylene glycol, then loaded with lamivudine and crosslinked by sodium tri polyphosphate (TPP) to produce lamivudine nanodrug in a chitosan drug delivery system. According to the particle size analyzer (PSA), nanodrug has particle size approximately 79.25 nm. The encapsulation efficiency of nanodrug is 86.96 % from 28.98 % loading concentration. The drug release tests of lamivudine in phosphate buffer at pH of 3.0 for 4 h; pH of 6.8 and 7.4 for 24 h were 72.37; 84.96 and 80.40 % respectively.

KW - Lamivudine

KW - antiretroviral

KW - chitosan nanoparticle

KW - nanodrug

UR - https://www.scopus.com/pages/publications/85086644153

U2 - 10.1063/5.0007925

DO - 10.1063/5.0007925

M3 - Conference contribution

AN - SCOPUS:85086644153

T3 - AIP Conference Proceedings

BT - Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019

A2 - Mart, Terry

A2 - Triyono, Djoko

A2 - Ivandini, Tribidasari Anggraningrum

PB - American Institute of Physics Inc.

T2 - 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019

Y2 - 9 July 2019 through 10 July 2019

ER -

Astuti S, Yulizar Y , Saefumillah A , Apriandanu DOB. Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system. In Mart T, Triyono D, Ivandini TA, editors, Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019. American Institute of Physics Inc. 2020. 040029. (AIP Conference Proceedings). doi: 10.1063/5.0007925

Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system

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Keywords

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