Chitosan nanoparticles modified by polyethylene glycol as lamivudine drug delivery system

S. Astuti, Y. Yulizar, A. Saefumillah, D. O.B. Apriandanu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Lamivudine is an antiretroviral (ARV) drug from category of nucleoside reverse transcriptase inhibitors (NRTI) for both the human immunodeficiency virus (HIV) and hepatitis B treatments. Besides, chitosan in nanoparticles is used as a matrix in good drug delivery systems for both hydrophobic and hydrophilic ARV drugs. Chitosan modification has been widely investigated to enhance its hydrophilicity properties to bind lamivudine. This study aims to modify chitosan nanoparticles (CSNP) using polyethylene glycol as a drug delivery system for lamivudine. CSNP was modified by polyethylene glycol, then loaded with lamivudine and crosslinked by sodium tri polyphosphate (TPP) to produce lamivudine nanodrug in a chitosan drug delivery system. According to the particle size analyzer (PSA), nanodrug has particle size approximately 79.25 nm. The encapsulation efficiency of nanodrug is 86.96 % from 28.98 % loading concentration. The drug release tests of lamivudine in phosphate buffer at pH of 3.0 for 4 h; pH of 6.8 and 7.4 for 24 h were 72.37; 84.96 and 80.40 % respectively.

Original languageEnglish
Title of host publicationProceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
EditorsTerry Mart, Djoko Triyono, Tribidasari Anggraningrum Ivandini
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735420014
DOIs
Publication statusPublished - 1 Jun 2020
Event5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 - Depok, Indonesia
Duration: 9 Jul 201910 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2242
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
Country/TerritoryIndonesia
CityDepok
Period9/07/1910/07/19

Keywords

  • antiretroviral
  • chitosan nanoparticle
  • Lamivudine
  • nanodrug

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