Chitosan microparticles for in vitro release of acetogenins extracted from Annona muricata L. leaves

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Chitosan microparticles were prepared for extended release of acetogenins extracted from the leaves of Annona muricata L., known as soursop. The acetogenin extract was encapsulated in chitosan microparticles prepared using sodium tripolyphosphate as the crosslinking agent. The possible interactions between the microparticle components were analyzed based on their FTIR absorption peaks. The effect of the experimental variables (acetogenin to chitosan mass ratio, amount of tripolyphosphate, presence of enzymes) on the 24-h in vitro cumulative release of acetogenins encapsulated in the chitosan microparticles and immersed in simulated gastrointestinal fluids, is presented. The sequential release in simulated (gastric, intestinal, colonic) fluids for 24 h period, facilitated higher cumulative release of acetogenins, indicating the potential of acetogenin-loaded microparticles for anticancer therapy purposes.

Original languageEnglish
Title of host publication3rd International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2020
EditorsIs Fatimah, Won-Chun Oh, Imam Sahroni
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735441262
DOIs
Publication statusPublished - 1 Sep 2021
Event3rd International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2020 - Yogyakarta, Indonesia
Duration: 30 Sep 2020 → …

Publication series

NameAIP Conference Proceedings
Volume2370
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2020
Country/TerritoryIndonesia
CityYogyakarta
Period30/09/20 → …

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