TY - GEN
T1 - Chitosan-alginate matrices loaded with leaf extracts of Anredera cordifolia Steenis as a gastrointestinal extended-release formulation
AU - Krisanti, Elsa Anisa
AU - Wahyunisa, Mutiara Primaster
AU - Hijrianti, Nugrahirani
AU - Mulia, Kamarza
N1 - Funding Information:
The authors are grateful for financial support from the Universitas Indonesia through the DRPM PITTA project No. NKB-0723/UN2.R3.1/HKP.05.00/2019
Publisher Copyright:
© 2019 Author(s).
PY - 2019/12/10
Y1 - 2019/12/10
N2 - The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the ionotropic gelation methodwith tripolyphosphate as the cross-linking agent. Scanning electron microscope and Fourier transform infrared spectroscopy was used to investigate the surface morphology and the structure of the matrices, respectively. The effect of alginate addition was studied by determining the physical characteristics of the matrices, encapsulation efficiency, loading capacity, matrix yield, as well as the release profiles of the bioactive compounds in simulated gastrointestinal fluids. The bioactive compounds in the leaf extracts and matrices, quantified as total phenolics, were determined using UV-spectrophotometry. High-performance liquid chromatography was used to determine the amount of vitexin present in the leaf extracts. The encapsulation efficiency of the phenolic compounds was at least 90%, the highest loading capacity was 1.23%, and matrix yield was at least 83%. The in vitro release assays showed a reduced cumulative release of phenolic compounds in synthetic gastric fluid (35 to 12%), and, in three synthetic gastrointestinal fluids (71 to 50%) after 24 hours, due to the addition of alginate in the chitosan matrix. These results indicate the possibility of employing chitosan-alginate matrixto shift the release of phenolics of Anredera cordifolia extracts from the gastric area to the colon area.
AB - The development of chitosan-alginate matrices loaded with Anredera cordifolia Steenis (Madeira-vine) leaf extract as an extended-release formulation is herewith described. Madeira-vine plants have been known used traditionally to treat various ailments such as anti-inflammation, hypertension, and skin diseases. The matrices were prepared using the ionotropic gelation methodwith tripolyphosphate as the cross-linking agent. Scanning electron microscope and Fourier transform infrared spectroscopy was used to investigate the surface morphology and the structure of the matrices, respectively. The effect of alginate addition was studied by determining the physical characteristics of the matrices, encapsulation efficiency, loading capacity, matrix yield, as well as the release profiles of the bioactive compounds in simulated gastrointestinal fluids. The bioactive compounds in the leaf extracts and matrices, quantified as total phenolics, were determined using UV-spectrophotometry. High-performance liquid chromatography was used to determine the amount of vitexin present in the leaf extracts. The encapsulation efficiency of the phenolic compounds was at least 90%, the highest loading capacity was 1.23%, and matrix yield was at least 83%. The in vitro release assays showed a reduced cumulative release of phenolic compounds in synthetic gastric fluid (35 to 12%), and, in three synthetic gastrointestinal fluids (71 to 50%) after 24 hours, due to the addition of alginate in the chitosan matrix. These results indicate the possibility of employing chitosan-alginate matrixto shift the release of phenolics of Anredera cordifolia extracts from the gastric area to the colon area.
KW - Alginate
KW - Anredera cordifolia steenis
KW - chitosan
KW - extended release
UR - http://www.scopus.com/inward/record.url?scp=85076763654&partnerID=8YFLogxK
U2 - 10.1063/1.5139338
DO - 10.1063/1.5139338
M3 - Conference contribution
AN - SCOPUS:85076763654
T3 - AIP Conference Proceedings
BT - 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
A2 - Lischer, Kenny
A2 - Abuzairi, Tomy
A2 - Rahman, Siti Fauziyah
A2 - Gozan, Misri
PB - American Institute of Physics Inc.
T2 - 4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
Y2 - 22 July 2019 through 24 July 2019
ER -