Chemical constituents of Garcinia maingayii

Sri Hartati; Hong Bing Wang; L. B.S. Kardono; Soleh Kosela; Guo Wei Qin

Chemical constituents of Garcinia maingayii

Sri Hartati, Hong Bing Wang, L. B.S. Kardono, Soleh Kosela, Guo Wei Qin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Aim: To study the bioactive chemical constituents of Garcinia maingayii Hook. Methods: Repeated column chromatography was used for separation of compounds and spectroscopic techniques and X-ray analysis were used for structure determination. Results: Five known compounds, isoxanthochymol (1), camboginol (2) 5, 7, 2′, 5′-tetrahydroxy flavan-3-o1 (3), stigmasterol (4) and griffipavixanthone (5) were obtained from hexane and acetone extracts of stem barks of the plant. Compounds 1, 2 and 5 showed high potential in vitro cytotoxicity against in P388 murine leukemia cells with IC₅₀ 1.47, 4.90 and 0.42 μg·mL^-1, respectively. Conclusion: Compounds 1-5 were first reported from this plant.

Original language	English
Pages (from-to)	272-276
Number of pages	5
Journal	Chinese Journal of Natural Medicines
Volume	5
Issue number	4
Publication status	Published - Jul 2007

Keywords

Camboginol
Cytoxicity
Garcinia maingayii
Isoxanthochymol

Cite this

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title = "Chemical constituents of Garcinia maingayii",

abstract = "Aim: To study the bioactive chemical constituents of Garcinia maingayii Hook. Methods: Repeated column chromatography was used for separation of compounds and spectroscopic techniques and X-ray analysis were used for structure determination. Results: Five known compounds, isoxanthochymol (1), camboginol (2) 5, 7, 2′, 5′-tetrahydroxy flavan-3-o1 (3), stigmasterol (4) and griffipavixanthone (5) were obtained from hexane and acetone extracts of stem barks of the plant. Compounds 1, 2 and 5 showed high potential in vitro cytotoxicity against in P388 murine leukemia cells with IC50 1.47, 4.90 and 0.42 μg·mL-1, respectively. Conclusion: Compounds 1-5 were first reported from this plant.",

keywords = "Camboginol, Cytoxicity, Garcinia maingayii, Isoxanthochymol",

author = "Sri Hartati and Wang, {Hong Bing} and Kardono, {L. B.S.} and Soleh Kosela and Qin, {Guo Wei}",

year = "2007",

month = jul,

language = "English",

volume = "5",

pages = "272--276",

journal = "Chinese Journal of Natural Medicines",

issn = "1672-3651",

publisher = "China Pharmaceutical University",

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TY - JOUR

T1 - Chemical constituents of Garcinia maingayii

AU - Hartati, Sri

AU - Wang, Hong Bing

AU - Kardono, L. B.S.

AU - Kosela, Soleh

AU - Qin, Guo Wei

PY - 2007/7

Y1 - 2007/7

N2 - Aim: To study the bioactive chemical constituents of Garcinia maingayii Hook. Methods: Repeated column chromatography was used for separation of compounds and spectroscopic techniques and X-ray analysis were used for structure determination. Results: Five known compounds, isoxanthochymol (1), camboginol (2) 5, 7, 2′, 5′-tetrahydroxy flavan-3-o1 (3), stigmasterol (4) and griffipavixanthone (5) were obtained from hexane and acetone extracts of stem barks of the plant. Compounds 1, 2 and 5 showed high potential in vitro cytotoxicity against in P388 murine leukemia cells with IC50 1.47, 4.90 and 0.42 μg·mL-1, respectively. Conclusion: Compounds 1-5 were first reported from this plant.

AB - Aim: To study the bioactive chemical constituents of Garcinia maingayii Hook. Methods: Repeated column chromatography was used for separation of compounds and spectroscopic techniques and X-ray analysis were used for structure determination. Results: Five known compounds, isoxanthochymol (1), camboginol (2) 5, 7, 2′, 5′-tetrahydroxy flavan-3-o1 (3), stigmasterol (4) and griffipavixanthone (5) were obtained from hexane and acetone extracts of stem barks of the plant. Compounds 1, 2 and 5 showed high potential in vitro cytotoxicity against in P388 murine leukemia cells with IC50 1.47, 4.90 and 0.42 μg·mL-1, respectively. Conclusion: Compounds 1-5 were first reported from this plant.

KW - Camboginol

KW - Cytoxicity

KW - Garcinia maingayii

KW - Isoxanthochymol

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M3 - Article

AN - SCOPUS:34547536857

SN - 1672-3651

VL - 5

SP - 272

EP - 276

JO - Chinese Journal of Natural Medicines

JF - Chinese Journal of Natural Medicines

IS - 4

ER -

Chemical constituents of Garcinia maingayii

Abstract

Keywords

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