Abstract
Aim: To study the bioactive chemical constituents of Garcinia maingayii Hook. Methods: Repeated column chromatography was used for separation of compounds and spectroscopic techniques and X-ray analysis were used for structure determination. Results: Five known compounds, isoxanthochymol (1), camboginol (2) 5, 7, 2′, 5′-tetrahydroxy flavan-3-o1 (3), stigmasterol (4) and griffipavixanthone (5) were obtained from hexane and acetone extracts of stem barks of the plant. Compounds 1, 2 and 5 showed high potential in vitro cytotoxicity against in P388 murine leukemia cells with IC50 1.47, 4.90 and 0.42 μg·mL-1, respectively. Conclusion: Compounds 1-5 were first reported from this plant.
Original language | English |
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Pages (from-to) | 272-276 |
Number of pages | 5 |
Journal | Chinese Journal of Natural Medicines |
Volume | 5 |
Issue number | 4 |
Publication status | Published - Jul 2007 |
Keywords
- Camboginol
- Cytoxicity
- Garcinia maingayii
- Isoxanthochymol