Characterization of human lymphocyte subpopulations for cytotoxicity against tumor‐derived monolayer cultures

Tibor Bakæcs, Peter Gergely, Santoso Cornain, Eva Klein

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Lymphocyte fractions of three healthy donors were tested for cytotoxicity in a 48‐h assay on several tumor‐derived lines. Analysis of surface markers indicated that a non‐T non‐B fraction comprising about 50% Fc‐receptor‐positive cells was most potent. The cell yield in this fraction was on the average 6.5% of the non‐fractionated population. Elimination of SIg positive cells did not influence the cytotoxic potential. Pure T cells isolated with E‐rosetting subsequent to passage on nylon wool column had no or very low cytotoxicity. We had indications that cells without conventional markers —“null” cells—were also cytotoxic.

Original languageEnglish
Pages (from-to)441-449
Number of pages9
JournalInternational Journal of Cancer
Volume19
Issue number4
DOIs
Publication statusPublished - 1 Jan 1977

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