Characterization of granular calcium sulfate dihydrate-gelatin composite for bone void filler

Yosi Kusuma Eriwati, Difa Putri Utami, Dede Arsista, Sunarso, Siti Triaminingsih

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Calcium sulfate dihydrate (CSD) cement has been used as bone filler for decades. It is also used as antibiotics carrier to treat osteomyelitis. However, CSD cement itself when applied at bone defect has some limitation such as its brittleness. The brittleness limits its handling property. Thus, the aim of this study is to fabricate granular CSD cement-gelatin (CSD-Gel) that has good handling property to be used as bone void filler. To prepare CSD-Gel composite, granular CSD was prepared from calcium sulfate hemihydrate (CaSO4.0.5H2O; CSH) and distilled water with water/powder (W/P) ratio of 0.5. The CSD cement was crushed and sieved into 300-500 µm. The obtained granular CSD was then mixed with 3 wt.% and 7 wt.% gelatin solution, followed by freeze drying for 48 hours. The CSD granules were surrounded by gelatin matrix in all specimens. It was observed that more gelatin matrix found in the space between the granules in in the composite with 7 wt% gelatin compared with that in 3 wt% gelatin. Mechanical evaluation revealed that CSD-Gel 7% has significant higher compressive strength compared to CSD-Gel 3%.

Original languageEnglish
Title of host publicationAsian BioCeramics 18
EditorsArief Cahyanto, Arief Cahyanto, I Made Joni, I Made Joni
PublisherTrans Tech Publications Ltd
Number of pages6
ISBN (Print)9783035714395
Publication statusPublished - 1 Jan 2020
Event18th Asian BioCeramics Symposium, ABC 2018 - Bandung, Indonesia
Duration: 19 Sept 201820 Sept 2018

Publication series

NameKey Engineering Materials
Volume829 KEM
ISSN (Print)1013-9826


Conference18th Asian BioCeramics Symposium, ABC 2018


  • Bone filler
  • Calcium sulfate dihydrate
  • Composite
  • Gelatin
  • Void filler


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