Characterization of dengue virus serotype 4 infection in Jakarta, indonesia

Beti Ernawati Dewi, Leonard Naiggolan, Dwi Hilda Putri, Novia Rachmayanti, Sarah Albar, Nadia Tita Indriastuti, Wellyzar Sjamsuridzal, Tjahjani Mirawati Sudiro

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18 Citations (Scopus)


Dengue hemorrhagic fever has become a worldwide health issue. Heterologous infection by different serotypes may lead to severe forms of dengue infection and even death. In a cohort study in Jakarta from 2009 to 2010 with inclusion criteria of adults with fever of less than 48 hours, 72% were confirmed dengue infection from a total of suspected 190 dengue patients. Using RT-PCR, 16 patients were infected with DENV-4 with or without co-infection with other serotype(s). Dengue fever (DF) patients (73%) were infected with DENV-4 alone, while mixed infections were present in more severe clinical manifestations of DHF grade I and II. The nucleotide sequences of envelope (E) protein gene of 3 isolates of DENV-4 showed that they belonged to genotype II. There were 50 nucleotide substitutions, but only 3 amino acid changes were found at positions 130, 233 and 455, present in E protein isolated from DHF grade II patient.

Original languageEnglish
Pages (from-to)53-61
Number of pages9
JournalSoutheast Asian Journal of Tropical Medicine and Public Health
Issue number1
Publication statusPublished - 2014


  • Dengue virus serotype 4
  • Genotype II
  • Indonesia
  • Serotype mixed infection


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