Hypertension, which often dubbed as “silent killer”, is a global health problem due to high prevalence worldwide and led to several diseases such as coronary heart attack and stroke. To treat this disease, nifedipine (NIF) is usually being consumed to reduce the high blood pressure into normal. However, the repetitive dosage of this drug may cause a side effect that can lower the effectiveness of this treatment. Thus, the controlled drug delivery system is utilized to increase the effectivity of NIF with the optimal daily dose. In this research, the polyblend of poly(lactic acid) (PLA) and poly(Ɛ-caprolactone) (PCL) was synthesized to encapsulate NIF using oil-in-water (o/w) solvent evaporation method, while the emulsion stirring speed, Tween 80 concentration, dispersion time, and emulsion time were varied to find the optimum conditions for composing the microcapsule. Throughout this research, the optimum conditions of microcapsule production have occurred in a stirring speed of 700 rpm, dispersion time of 1 hour, Tween 80 concentration of 0.5%, and emulsion time of 1 hour. Furthermore, the drug efficiency value was determined at 97.40%. Finally, the microcapsule size was observed at 20-23 μM, with the 23.19 μM was determined as the optimum size of the respective microcapsule.