TY - GEN
T1 - Characterization and efficiency test of nifedipine (Nif) microencapsulation using polyblend of poly(lactic acid) and poly(Ɛ-caprolactone)
AU - Wati, Galuh Putri Erika
AU - Hayatunnufus, Rahmi
AU - Budianto, Emil
N1 - Funding Information:
This research was fully funded by Hibah Publikasi Terindeks Internasional Untuk Tugas Akhir Mahasiswa Universitas Indonesia (PITTA UI) No: 2262/UN2.R3.1/HKP05.00/2018. Thus, none conflict of interests are declared.
Publisher Copyright:
© 2019 Trans Tech Publications, Switzerland.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Hypertension, which often dubbed as “silent killer”, is a global health problem due to high prevalence worldwide and led to several diseases such as coronary heart attack and stroke. To treat this disease, nifedipine (NIF) is usually being consumed to reduce the high blood pressure into normal. However, the repetitive dosage of this drug may cause a side effect that can lower the effectiveness of this treatment. Thus, the controlled drug delivery system is utilized to increase the effectivity of NIF with the optimal daily dose. In this research, the polyblend of poly(lactic acid) (PLA) and poly(Ɛ-caprolactone) (PCL) was synthesized to encapsulate NIF using oil-in-water (o/w) solvent evaporation method, while the emulsion stirring speed, Tween 80 concentration, dispersion time, and emulsion time were varied to find the optimum conditions for composing the microcapsule. Throughout this research, the optimum conditions of microcapsule production have occurred in a stirring speed of 700 rpm, dispersion time of 1 hour, Tween 80 concentration of 0.5%, and emulsion time of 1 hour. Furthermore, the drug efficiency value was determined at 97.40%. Finally, the microcapsule size was observed at 20-23 μM, with the 23.19 μM was determined as the optimum size of the respective microcapsule.
AB - Hypertension, which often dubbed as “silent killer”, is a global health problem due to high prevalence worldwide and led to several diseases such as coronary heart attack and stroke. To treat this disease, nifedipine (NIF) is usually being consumed to reduce the high blood pressure into normal. However, the repetitive dosage of this drug may cause a side effect that can lower the effectiveness of this treatment. Thus, the controlled drug delivery system is utilized to increase the effectivity of NIF with the optimal daily dose. In this research, the polyblend of poly(lactic acid) (PLA) and poly(Ɛ-caprolactone) (PCL) was synthesized to encapsulate NIF using oil-in-water (o/w) solvent evaporation method, while the emulsion stirring speed, Tween 80 concentration, dispersion time, and emulsion time were varied to find the optimum conditions for composing the microcapsule. Throughout this research, the optimum conditions of microcapsule production have occurred in a stirring speed of 700 rpm, dispersion time of 1 hour, Tween 80 concentration of 0.5%, and emulsion time of 1 hour. Furthermore, the drug efficiency value was determined at 97.40%. Finally, the microcapsule size was observed at 20-23 μM, with the 23.19 μM was determined as the optimum size of the respective microcapsule.
KW - Efficiency
KW - Microencapsulation
KW - Nifedipine
KW - Poly(lactic acid)
KW - Poly(Ɛ-caprolactone)
KW - Solvent evaporation o/w
KW - Tween 80
UR - http://www.scopus.com/inward/record.url?scp=85066270015&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/MSF.947.26
DO - 10.4028/www.scientific.net/MSF.947.26
M3 - Conference contribution
AN - SCOPUS:85066270015
SN - 9783035714302
T3 - Materials Science Forum
SP - 26
EP - 31
BT - Nano Engineering and Materials Technologies III
A2 - Umemura, Kazuo
PB - Trans Tech Publications Ltd
T2 - 7th International Conference on Nanostructures, Nanomaterials and Nanoengineering, ICNNN 2018 and International Conference on Materials Technology and Applications, ICMTA 2018
Y2 - 26 October 2018 through 29 October 2018
ER -