Characterization and concentration optimization of hibiscus rosa-sinensis l. Mucilage powder as superdisintegrant

Imam Prabowo, Iskandarsyah, Rina Adriany

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The main purpose of this study is to characterize Hibiscus rosa-sinensis L. mucilage (MHR) powder as superdisintegrant and to decide the optimum concentration of Hibiscus rosa-sinensis L. Methods: Characterization was conducted in many tests such as organoleptic, swelling ratio, solubility, polysaccharide, viscosity, particle size distribution, flowability and compressibility index. Next, MHR powder was included in fast disintegrating tablet (FDT) domperidone formulation in several concentrations and compared with FDT domperidone formulation that using sodium starch glycolate as superdisintegrant. Results: The result of characterization of MHR powder were brownish powder, specific smell like traditional medicines, swelling ratio of 24, solubility of 0.426±0.034 mg/ml, positive polysaccharide, the viscosity of 491.33±119.44 cps (2% w/v), 4520.00±1224.42 cps (4% w/v), Dv(10) of 26.2 µm, Dv(50) of 157 µm, Dv(90) of 260 µm, Dv(100) of 380 µm, flowless, and average compressibility index of 26.75±1.79%. The optimum MHR powder concentration was 1% because the average disintegration time was 39.67±4.73 seconds and the average wetting time was 66.33±14.29 seconds. Those times were faster than domperidone FDT that used this superdisintegrant in other concentrations or sodium starch glycolate in the same concentration. Conclusion: Hibiscus rosa-sinensis L. mucilage powder can be used as superdisintegrant in FDT formulation with an optimum concentration of 1%.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalInternational Journal of Applied Pharmaceutics
Volume13
Issue numberSpecial Issue 2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • Fast disintegrating tablet
  • Hibiscus rosa-sinensis L
  • Superdisintegrant

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