Characteristics and Correlation Between Progesterone Receptors and The Use of Hormonal Contraceptive in Women with Meningioma in dr. Cipto Mangunkusumo National General Hospital

Meningiomas are the most common primary, intracranial and extra axial tumours, estimated for 30% of all intracranial tumors. The use of hormonal contraceptive is one of the risk factors for meningioma, but the studies still have controversial results. The purpose of this study is to describe the characteristics and to correlate between progesterone receptor and the use of hormonal contraceptive in women diagnosed with brain tumor meningioma. This is a cross-sectional study which collect data in dr. Cipto Mangunkusumo National General Hospital in the year 2017-2018. Patient data collection was obtained through the patient’s medical records, whereas the subjects are women with brain tumors meningioma who have undergone surgery. We found 72 women diagnosed with meningioma; however, only 54 subjects were included in this study. Immunohistochemistry staining were performed to all the 54 subjects and revealed that 53 subjects (98.15%) had positive progesterone receptors and only 1 subject was negative (1.85%). Of the 53 subjects with positive progesterone receptors, 48 subjects used hormonal contraceptive (90.57%), with 43 (89.58%) of them used 3 month injectable contraceptive. There is no correlation between progesterone receptors and the use of hormonal contraceptives in female patients with meningioma brain tumor (p value >0.999, Fisher Test).