TY - JOUR
T1 - Changes in Interleukin-1β, Tumor Necrosis Factor-α, and Interleukin-10 Cytokines in Older People with Periodontitis
AU - Sumbayak, Ines Augustina
AU - Masulili, Sri Lelyati C.
AU - Tadjoedin, Fatimah Maria
AU - Sulijaya, Benso
AU - Mutiara, Arrum
AU - Khoirowati, Diana
AU - Soeroso, Yuniarti
AU - Bachtiar, Boy M.
N1 - Funding Information:
This study was funded by a PUTI 2020 grant from the Research and Development Directorates, Universitas Indonesia (grant number: NKB-1602/UN2.RST/HKP.05.00/2020).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/8
Y1 - 2023/8
N2 - Aging can change the ability to respond to various stimuli and physical conditions. A decreased immune response is a form of deterioration of function in older people, who then become more vulnerable when exposed to pathogens. Periodontitis is an inflammatory disease of the periodontal tissues that often occurs in older people. This study aimed to clinically analyze the periodontal status and cytokine levels of IL-1β, TNF-α, and IL-10 in older people and adults with periodontitis. This clinical study examined 20 persons in a group of older people and 20 persons in a group of adults. The clinical measurements of periodontal status included the Simplified Oral Hygiene Index (OHI-S), Plaque Index (PlI), and Papilla Bleeding Index (PBI). The cytokine levels in gingival crevicular fluid (GCF) were quantified by using ELISA kits. The OHI-S, PlI, and PBI were found to be higher in the older group. The mean values of cytokines were higher in the older group than in adults, although no statistically significant differences were found. A strong correlation was found between the clinical measurements and the cytokine levels in the GCF. There was an increasing tendency of pro-inflammatory and anti-inflammatory cytokines in the older group compared to the adult group.
AB - Aging can change the ability to respond to various stimuli and physical conditions. A decreased immune response is a form of deterioration of function in older people, who then become more vulnerable when exposed to pathogens. Periodontitis is an inflammatory disease of the periodontal tissues that often occurs in older people. This study aimed to clinically analyze the periodontal status and cytokine levels of IL-1β, TNF-α, and IL-10 in older people and adults with periodontitis. This clinical study examined 20 persons in a group of older people and 20 persons in a group of adults. The clinical measurements of periodontal status included the Simplified Oral Hygiene Index (OHI-S), Plaque Index (PlI), and Papilla Bleeding Index (PBI). The cytokine levels in gingival crevicular fluid (GCF) were quantified by using ELISA kits. The OHI-S, PlI, and PBI were found to be higher in the older group. The mean values of cytokines were higher in the older group than in adults, although no statistically significant differences were found. A strong correlation was found between the clinical measurements and the cytokine levels in the GCF. There was an increasing tendency of pro-inflammatory and anti-inflammatory cytokines in the older group compared to the adult group.
KW - aging
KW - cytokine
KW - inflammation
KW - periodontal disease
KW - periodontitis
UR - http://www.scopus.com/inward/record.url?scp=85169084351&partnerID=8YFLogxK
U2 - 10.3390/geriatrics8040079
DO - 10.3390/geriatrics8040079
M3 - Article
AN - SCOPUS:85169084351
SN - 2308-3417
VL - 8
JO - Geriatrics (Switzerland)
JF - Geriatrics (Switzerland)
IS - 4
M1 - 79
ER -