The COVID-19 pandemic has changed the way learning is conducted in several countries. Face-to-face interaction has been prohibited to help prevent the spread of the virus even further. This situation has necessitated the transition from face-to-face to long distance learning. Lecturers' participation in using e-Learning platforms is one of the main factors that has influenced the transition. However, lecturers have faced many challenges during the transition period. Those challenges must be identified so that institutions can provide the support lecturers need. This study aims to identify the challenges and opportunities that come from online learning based on the lecturer’s perspective. A systematic literature review (SLR) is used to identify challenges and opportunities of online learning from previous studies. The findings of the current study show three major themes related to these challenges: individual, institutional, and technological. Furthermore, it finds that online learning provides opportunities to explore new ways of teaching and using technology for learning purposes, such as utilizing online learning tools for course assignments or quizzes.