TY - JOUR
T1 - Chalcones bearing N, O, and S-heterocycles
T2 - Recent notes on their biological significances
AU - Ardiansah, Bayu
N1 - Publisher Copyright:
© 2019 Bayu Ardiansah.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Because of its relatively easy synthesis, chalcone skeleton has been as a point of interest for organic and medicinal chemists from research groups worldwide. Chalcone scaffold constitutes the core of some interesting biologically active natural products. Chalcone derivatives are among feasible potent active agents, such as anticancer, antibacterial, antifungal, antileishmanial, antimalarial, and antiviral. Due to the knowledge of heterocyclic chemistry, recently chalcones bearing heterocyclic moieties have been synthesized and biologically investigated for specific target of diseases. The current review focuses on the latest application of chalcones integrated with N, O, and S-heterocyclic system and their wide spectrum of biological performance during 10 years (2010-2019). The results reported in the review indicate that many chalcone-heterocycle hybrids may be useful as future drug candidates due to their comparable or higher activity than that of the standards.
AB - Because of its relatively easy synthesis, chalcone skeleton has been as a point of interest for organic and medicinal chemists from research groups worldwide. Chalcone scaffold constitutes the core of some interesting biologically active natural products. Chalcone derivatives are among feasible potent active agents, such as anticancer, antibacterial, antifungal, antileishmanial, antimalarial, and antiviral. Due to the knowledge of heterocyclic chemistry, recently chalcones bearing heterocyclic moieties have been synthesized and biologically investigated for specific target of diseases. The current review focuses on the latest application of chalcones integrated with N, O, and S-heterocyclic system and their wide spectrum of biological performance during 10 years (2010-2019). The results reported in the review indicate that many chalcone-heterocycle hybrids may be useful as future drug candidates due to their comparable or higher activity than that of the standards.
KW - Biological activity
KW - Chalcones
KW - Heterocyclic
KW - N
KW - O
KW - Potent drugs
KW - S-heteroaromatic
UR - http://www.scopus.com/inward/record.url?scp=85071255823&partnerID=8YFLogxK
U2 - 10.7324/JAPS.2019.90816
DO - 10.7324/JAPS.2019.90816
M3 - Article
AN - SCOPUS:85071255823
SN - 2231-3354
VL - 9
SP - 117
EP - 129
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 8
ER -