The use of computational fluid dynamics (CFD) in cross-flow turbine pico sclae (CFT) numerical simulation is increased in several years using various methods. This study will explain step-by-step of cross-flow turbine pico sclae CFT numerical simulation using six degree of freedom (6-DOF) feature inside ANSYS® Fluent™ 18. The novel method in this study could be applied in future works. The simulation is running in two-dimensional domain and use SST model for turbulence phenomena modelling. Based on analysis, the number of mesh is 64k elements and timestep size of 0.0004 seconds is used because they have error below 1%. The numerical calculation results are lower than experimental results. Moreover, the average deviation between using 6-DOF approach numerical simulation and the experiment results in previous studies of around 6.8%. Thus, the 6-DOF approach can be used for CFT numerical studies.