TY - JOUR
T1 - Cd30 expression in germinal center b-cell-like and non-germinal center b-cell-like subtypes of diffuse large b-cell lymphoma
AU - Julianty, Patricia Fransisca
AU - Ham, Maria Francisca
AU - Kusmardi, Kusmardi
AU - Harahap, Agnes Stephanie
N1 - Funding Information:
Edited by: Ksenija Bogoeva-Kostovska Citation: Julianty PF, Ham MF, Kusmardi K, Harahap AS. CD30 Expression in Germinal Center B-cell-like and non-germinal Center B-cell-like Subtypes of Diffuse Large B-cell Lymphoma. Open-Access Maced J Med Sci. 2020 Apr 17; 8(B):375-380. https://doi.org/10.3889/oamjms.2020.4645 Keywords: CD30; Diffuse large B-cell lymphoma; Germinal-center B cell-like; non-germinal-center B cell-like *Correspondence: Kusmardi Kusmardi, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia. Phone: 62-813-919-7-444. Fax: 622131934465. E-mail: kusmardi.ms@ui.ac.id Received: 15-Aug-2019 Revised: 14-Mar-2020 Accepted: 16-Mar-2020 Copyright: © 2020 Ahmed Moustafa Wedn, Ahmed Eldamaty, Rania Elsherif, Hesham Alaasar, Moataz Elhalag Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Directorate of Research and Community Engagement Universitas Indonesia for the 2019 Universitas Indonesia Research Grant (NKB-0538/UN2.R3.1/HKP.05.00/2019). Competing Interests: The authors have declared that no competing interests exist Open Access: This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
Publisher Copyright:
© 2020 Ahmed Moustafa Wedn, Ahmed Eldamaty, Rania Elsherif, Hesham Alaasar, Moataz Elhalag.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/4/17
Y1 - 2020/4/17
N2 - BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most common and most heterogeneous type of nonHodgkin lymphoma. With current therapeutic modalities, 30%–40% of DLBCL cases still experience recurrence. The discovery of CD30 expression in DLBCL in several studies has opened up alternative opportunities for new target therapies. AIM: This cross-sectional study aimed to determine CD30 expression in DLBCL and its difference in expression in germinal center B-cell such as (GCB) and non-GCB subtypes. METHODS: The sample consisted of 25 GCB and 25 non-GCB cases based on immunohistochemical examination performed at Cipto Mangunkusumo Hospital from 2014 to 2017. CD30 staining was carried out and assessed using tumor cells percentage with positive cutoff values of >0%, >10%, and >20%. RESULTS: Positive CD30 expression was obtained in 8 (16%), 4 (8%), and 3 (6%), out of 50 DLBCL cases with positive cutoff values of >0%, >10%, and >20%, respectively. We performed Fisher’s exact test to determine CD30 expression in the GCB and non-GCB subtypes and found no significant difference with p > 0.05. CONCLUSION: Our study found no significant difference between CD30 expression in the GCB and non-GCB subtypes of DLBCL.
AB - BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most common and most heterogeneous type of nonHodgkin lymphoma. With current therapeutic modalities, 30%–40% of DLBCL cases still experience recurrence. The discovery of CD30 expression in DLBCL in several studies has opened up alternative opportunities for new target therapies. AIM: This cross-sectional study aimed to determine CD30 expression in DLBCL and its difference in expression in germinal center B-cell such as (GCB) and non-GCB subtypes. METHODS: The sample consisted of 25 GCB and 25 non-GCB cases based on immunohistochemical examination performed at Cipto Mangunkusumo Hospital from 2014 to 2017. CD30 staining was carried out and assessed using tumor cells percentage with positive cutoff values of >0%, >10%, and >20%. RESULTS: Positive CD30 expression was obtained in 8 (16%), 4 (8%), and 3 (6%), out of 50 DLBCL cases with positive cutoff values of >0%, >10%, and >20%, respectively. We performed Fisher’s exact test to determine CD30 expression in the GCB and non-GCB subtypes and found no significant difference with p > 0.05. CONCLUSION: Our study found no significant difference between CD30 expression in the GCB and non-GCB subtypes of DLBCL.
KW - CD30
KW - Diffuse large B-cell lymphoma
KW - Germinal-center B cell-like
KW - Non-germinal-center B cell-like
UR - http://www.scopus.com/inward/record.url?scp=85089370018&partnerID=8YFLogxK
U2 - 10.3889/oamjms.2020.4645
DO - 10.3889/oamjms.2020.4645
M3 - Article
AN - SCOPUS:85089370018
VL - 8
SP - 375
EP - 380
JO - Open Access Macedonian Journal of Medical Sciences
JF - Open Access Macedonian Journal of Medical Sciences
SN - 1857-5749
IS - B
ER -