Catalytic performance of CuO@SiO2 for one-pot synthesis of pyrimidine derivative, ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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We have prepared a three-component reaction of ethyl acetoacetate, urea and benzaldehyde for synthesis of a pyrimidine derivative, ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate using CuO@SiO2, nanocatalyst. The catalyst was prepared by using glycerol as green solvent, and then it was characterized by FT-IR, EDAX spectroscopy and TEM analysis. The copper oxide nanoparticles are dispersed as fine and amorphous phase and made nanoclusters with average size of 14 nm. In pyrimidine derivative synthesis, the catalyst shows good activity for one-pot three-component reaction in mild reaction condition with the highest yield of 85%.

Original languageEnglish
Article number012052
JournalIOP Conference Series: Materials Science and Engineering
Issue number1
Publication statusPublished - 22 Feb 2019
Event2nd International Conference on Current Progress in Functional Materials 2017, ISCPFM 2017 - Bali, Indonesia
Duration: 8 Nov 20179 Nov 2017


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