Case definition of chronic pulmonary aspergillosis in resource-constrained settings

David W. Denning, Iain D. Page, Jeremiah Chakaya, Kauser Jabeen, Cecilia M. Jude, Muriel Cornet, Ana Alastruey-Izquierdo, Felix Bongomin, Paul Bowyer, Arunaloke Chakrabarti, Sara Gago, John Guto, Bruno Hochhegger, Martin Hoenigl, Muhammad Irfan, Nicholas Irurhe, Koichi Izumikawa, Bruce Kirenga, Veronica Manduku, Samihah MoazamRita O. Oladele, Malcolm D. Richardson, Juan Luis Rodriguez Tudela, Anna Rozaliyani, Helmut J.F. Salzer, Richard Sawyer, Nasilele F. Simukulwa, Alena Skrahina, Charlotte Sriruttan, Findra Setianingrum, Bayu A.P. Wilopo, Donald C. Cole, Haileyesus Getahun

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower-and middle-income countries as well as in resource-constrained settings.

Original languageEnglish
Pages (from-to)e1-e13
JournalEmerging Infectious Diseases
Volume24
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

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    Denning, D. W., Page, I. D., Chakaya, J., Jabeen, K., Jude, C. M., Cornet, M., Alastruey-Izquierdo, A., Bongomin, F., Bowyer, P., Chakrabarti, A., Gago, S., Guto, J., Hochhegger, B., Hoenigl, M., Irfan, M., Irurhe, N., Izumikawa, K., Kirenga, B., Manduku, V., ... Getahun, H. (2018). Case definition of chronic pulmonary aspergillosis in resource-constrained settings. Emerging Infectious Diseases, 24(8), e1-e13. https://doi.org/10.3201/eid2408.171312