TY - JOUR
T1 - Carotid intima-media thickness among normoglycemia and normotension first-degree relatives of type 2 diabetes mellitus
AU - Purnamasari, Dyah
AU - Abdaly, Muhammad Syah
AU - Azizi, Mohamad Syahrir
AU - Wijaya, Ika Prasetya
AU - Nugroho, Pringgodigdo
N1 - Funding Information:
The authors would like to thank Research and Society Services Directorate, Universitas Indonesia for supporting the finance of this research; and the Cluster Metabolic and Vascular Aging, Indonesian Medical Education and Research Institute (IMERI) team for their support in collecting blood sample and ultrasonography examination.
Publisher Copyright:
© 2019 Purnamasari et al.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Introduction: Theoretically, first-degree relatives (FDRs) of type 2 diabetes mellitus (T2DM) are predisposed to have earlier and more severe atherosclerosis than non-FDR due to hereditary insulin resistance. A previous study reported that atherosclerotic plaques were found in 45.2% of young adults FDR of T2DM, but the study did not include non-FDR as control group. The aim of this study was to compare subclinical atherosclerosis (carotid intima-media thickness, CIMT) between FDR of T2DM and non-FDR. Method: This was a cross-sectional study involving 16 FDR subjects and 16 age-sex matched non-FDR subjects, aged 19-40 years, with normal glucose tolerance and no hypertension. Collected data included demographic characteristic, anthropometric measurement (BMI and waist circumference), laboratory analysis (fasting blood glucose, HbA1c, lipid profile), and CIMT examination (using B-mode ultrasound). Results: The mean of CIMT in the FDR group was higher than that in the non-FDR group (0.44 mm vs 0.38 mm, p=0.005). After adjusting for waist circumference, BMI, low-density lipoprotein cholesterol, and triglyceride, CIMT maintained significant difference between FDR and non-FDR subjects. BMI and waist circumference showed moderate correlation with CIMT. Conclusion: CIMT in young adult FDR of T2DM is thicker than that in age-and sex-matched non-FDR population.
AB - Introduction: Theoretically, first-degree relatives (FDRs) of type 2 diabetes mellitus (T2DM) are predisposed to have earlier and more severe atherosclerosis than non-FDR due to hereditary insulin resistance. A previous study reported that atherosclerotic plaques were found in 45.2% of young adults FDR of T2DM, but the study did not include non-FDR as control group. The aim of this study was to compare subclinical atherosclerosis (carotid intima-media thickness, CIMT) between FDR of T2DM and non-FDR. Method: This was a cross-sectional study involving 16 FDR subjects and 16 age-sex matched non-FDR subjects, aged 19-40 years, with normal glucose tolerance and no hypertension. Collected data included demographic characteristic, anthropometric measurement (BMI and waist circumference), laboratory analysis (fasting blood glucose, HbA1c, lipid profile), and CIMT examination (using B-mode ultrasound). Results: The mean of CIMT in the FDR group was higher than that in the non-FDR group (0.44 mm vs 0.38 mm, p=0.005). After adjusting for waist circumference, BMI, low-density lipoprotein cholesterol, and triglyceride, CIMT maintained significant difference between FDR and non-FDR subjects. BMI and waist circumference showed moderate correlation with CIMT. Conclusion: CIMT in young adult FDR of T2DM is thicker than that in age-and sex-matched non-FDR population.
KW - carotid intima-media thickness
KW - first-degree relatives
KW - subclinical atherosclerosis
KW - type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=85068170295&partnerID=8YFLogxK
U2 - 10.2147/VHRM.S195776
DO - 10.2147/VHRM.S195776
M3 - Article
C2 - 31190848
AN - SCOPUS:85068170295
SN - 1176-6344
VL - 15
SP - 101
EP - 107
JO - Vascular Health and Risk Management
JF - Vascular Health and Risk Management
ER -
