Carboxymethyl chitosan/amorphous calcium phosphate and dentin remineralization

Teguh Santoso, Nila Kesuma Djauharie, Kamizar, Waviyatul Ahdi, Faurier Dzar Eljabbar Latief, Endang Suprastiwi

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) is a non-collagen protein analogue that can replace the dentin matrix protein 1 (DMP1) function. The aim of this study was to analyze the effects of CMC/ACP in demineralized dentin. Two groups of four teeth with eight cavities were created. Group 1 teeth were filled with composite resin, whereas group 2 teeth were first applied with CMC/ACP followed by filling with composite resin. Then, all teeth were soaked in phosphate-buffered saline solution and placed in a shaking incubator at 37°C. On days 7 and 14 of incubation, the gray areas of the samples were analyzed using micro-computed tomography. The gray area of group 2 increased on both days 7 (35.171 ± 5.547) and 14 (43.281 ± 4.834), whereas those of group 1 decreased on day 14 (27.100). Thus, CMC/ACP may induce dentin remineralization.

Original languageEnglish
Pages (from-to)84-87
Number of pages4
JournalJournal of International Dental and Medical Research
Issue number1
Publication statusPublished - 1 Jan 2019


  • Amorphous calcium phosphate
  • Carboxymethyl chitosan
  • Dental caries
  • Dentin
  • Remineralization


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