The photosynthetic of cyanobacterium Anabaena cylindrica strain IAM M1 in aerated liquid was preferred for high CO2 fixation at low temperature environmental condition. Cell growth successfully in single reactor at low temperature as 288K, however, in accordance with Arhenius prediction, biomass productin and average carbon dioxide removal relatively small. Current works was carried to improve the performance of photosynthetic in single reactor and consequently we proposed multi reactor series, which was, contained 5 reactors. The overall average value of carbon dioxide transfer rate (CTRav) of cyanobacterial growth in this multiple reactor series was around 0.321g/[dm 3.h], which was about two and half times of result in single reactor. Refer to average value of final cell concentration and light energy utility efficiency of cyanobacterial growth production (η), multiple reactor series also increased biomass production and actually, produced more efficient than in single reactor, which were approximately, three times. Additionally, kinetic studies of this microbial growth in multiple reactor series also concluded that both of relationship between specific carbon dioxide transfer rate q CO2 and X as essential factor concentration of carbon dioxide fixation and relationship between incident specific growth rate (ηφ) and [HCO3-] as essential compound concentration of cyanobacterial growth, followed a substrate inhibition model kinetic equation, that was proposed by Haldane.