Candidemia in Neonates with Antibiotic Therapeutic Failure

Retno Wahyuningsih, Anna Rozaliyani, Sjarifah Miftahul El Jannah, Idham Amir, Joedo Prihartono

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Fungal infection should be taken into consideration in neonates after the failure of adequate antibiotics therapy. The yeast Candida usually causes systemic mycosis. In this study, to determine the cause of systemic mycoses 1 ml of blood from the neonates with therapeutics failure was plating onto sabouraud dextrose agar. The isolates were further identify with sugar assimilation- fermentation test and continue with rice cream – Tween 80 agar for any doubtful results. The prevalence of systemic candidosis is 62.96% among neonates with therapeutic failure of antibiotics. Species identification showed C. tropicalis in the first rank followed by C. guilliermondii, C. albicans, C. glabrata, C. lusitaniae and T. variabile. The infection either multiple causes by more then one species or single infection. Failure of antibiotics therapy might be caused by fungal infection and it was concluded that there is a shift from C. albicans to Candida non C. albicans species as the cause of systemic infection, in this study by C. tropicalis.
Original languageEnglish
JournalJournal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Publication statusPublished - 2008


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