Cancer Associated Fibroblast (CAF) Expressed Podoplanin and LMVD Have No Correlation with Lymph Node Metastasis in Mucinous and Not Otherwise Specified (NOS) Colorectal Adenocarcinoma

This study will analyze and compare the role of CAF expressed podoplanin in lymphangiogenesis and tumor metastasis to lymph node between mucinous and NOS colorectal adenocarcinoma. The CAF expressed podoplanin was already studied in many malignant tumor include in colorectal carcinoma (CRC) but the result still in controversies. The study consists of 44 cases including 22 cases of mucinous adenocarcinoma and 22 cases of colorectal NOS adenocarcinoma. Podoplanin is used to see its expression in CAF and LMVD. CAF expressed podoplaninin in NOS adenocarcinoma is higher than mucinous adenocarcinoma (**p<0,01). There was no significant difference in LMVD values between mucinous adenocarcinoma and NOS adenocarcinoma (p = 0,381). There was no correlation between CAF expressed podoplanin with LMVD values in mucinous adenocarcinoma (p = 0,248) and NOS adenocarcinoma (p = 0,448). There was no significant correlation between CAF expressed podoplanin with lymph node metastasis in mucinous adenocarcinoma (p = 0,240) and NOS adenocarcinoma (p = 0,791). Recent years have brought new insights into the biological role of podoplanin. Not many research on CAF expressed podoplanin in CRC, especially musinosum adenocarcinoma. The diversity of the biological role of podoplanin in normal transformation tissues and cancer requires further research to better understand the interaction of cancer stroma with the process of lymphangiogenesis and lymph node metastasis such as VEGF, bFGF, heparin, histamine, TNF-α, angiopoeitin-1 and protease. TIE-2-Expressing Monocytes (TEM), they are also promote angiogenesis and tumor growth.