TY - JOUR
T1 - C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population
AU - Sauriasari, Rani
AU - Sakano, Noriko
AU - Wang, Da Hong
AU - Takaki, Jiro
AU - Takemoto, Kei
AU - Wang, Bingling
AU - Sugiyama, Hitoshi
AU - Sato, Yoshie
AU - Takigawa, Tomoko
AU - Takahashi, Noriko
AU - Kanbara, Sakiko
AU - Hitomi, Yoshiaki
AU - Nakamura, Hiroyuki
AU - Ogino, Keiki
PY - 2010/11
Y1 - 2010/11
N2 - Although cigarette smoking is known to be an important risk factor for renal disease, the mechanism by which smoking induces progressive renal disease in a healthy population has not been established. We hypothesized that oxidative stress (measured as 8-iso-prostaglandin F 2α, 8-iso-PGF2a), inflammation (highly sensitive C-reactive protein (CRP), hs-CRP) and nitric oxide may be associated with an alteration in the estimated glomerular filtration rate (eGFR) and proteinuria in otherwise healthy smokers. A total of 649 eligible subjects were classified according to their smoking status. Plasma NOx was measured using ozone-based chemiluminescence, urinary 8-iso-PGF2a was measured using enzyme immunoassay and serum hs-CRP was measured using a latex aggregation nephelometry method. The levels of 8-iso-PGF2a and hs-CRP increased in current smokers (P<0.001 and P<0.029, respectively), although there was not an increase in the NOx level. The prevalence of a high eGFR increased in light smokers (odds ratio (OR) 1.15 (95% confidence interval (CI), 0.61-2.17)) and heavy smokers (OR 2.33 (95% CI, 1.06-5.10)) when compared with non-and past smokers (P for trend0.024). The multivariable-adjusted mean values of the eGFR in current smokers, reported from the lowest to the highest quintiles of hs-CRP levels, were 82.1, 85.1, 86.4 and 88.5 ml per min per 1.73 m 2 (P for trend0.027). The mean values of proteinuria were 28.6, 34.6, 37.2 and 39.5 mg g 1 creatinine (P for trend0.003). The correlation coefficient between hs-CRP and eGFR was increased significantly (P<0.03) across non-(r0.03), past (r0.17), light (r0.13) and heavy smokers (r0.31). In conclusion, cigarette smoking is a risk factor for renal function alteration in healthy smokers and is characterized by a high eGFR and a high urinary protein associated with an increase in the hs-CRP. This finding suggests that hs-CRP may help mediate the alteration of renal function in smokers.
AB - Although cigarette smoking is known to be an important risk factor for renal disease, the mechanism by which smoking induces progressive renal disease in a healthy population has not been established. We hypothesized that oxidative stress (measured as 8-iso-prostaglandin F 2α, 8-iso-PGF2a), inflammation (highly sensitive C-reactive protein (CRP), hs-CRP) and nitric oxide may be associated with an alteration in the estimated glomerular filtration rate (eGFR) and proteinuria in otherwise healthy smokers. A total of 649 eligible subjects were classified according to their smoking status. Plasma NOx was measured using ozone-based chemiluminescence, urinary 8-iso-PGF2a was measured using enzyme immunoassay and serum hs-CRP was measured using a latex aggregation nephelometry method. The levels of 8-iso-PGF2a and hs-CRP increased in current smokers (P<0.001 and P<0.029, respectively), although there was not an increase in the NOx level. The prevalence of a high eGFR increased in light smokers (odds ratio (OR) 1.15 (95% confidence interval (CI), 0.61-2.17)) and heavy smokers (OR 2.33 (95% CI, 1.06-5.10)) when compared with non-and past smokers (P for trend0.024). The multivariable-adjusted mean values of the eGFR in current smokers, reported from the lowest to the highest quintiles of hs-CRP levels, were 82.1, 85.1, 86.4 and 88.5 ml per min per 1.73 m 2 (P for trend0.027). The mean values of proteinuria were 28.6, 34.6, 37.2 and 39.5 mg g 1 creatinine (P for trend0.003). The correlation coefficient between hs-CRP and eGFR was increased significantly (P<0.03) across non-(r0.03), past (r0.17), light (r0.13) and heavy smokers (r0.31). In conclusion, cigarette smoking is a risk factor for renal function alteration in healthy smokers and is characterized by a high eGFR and a high urinary protein associated with an increase in the hs-CRP. This finding suggests that hs-CRP may help mediate the alteration of renal function in smokers.
KW - 8-iso-PGF2a
KW - Cigarette smoking
KW - hs-CRP
KW - nitric oxide
KW - renal function
UR - http://www.scopus.com/inward/record.url?scp=78149303260&partnerID=8YFLogxK
U2 - 10.1038/hr.2010.154
DO - 10.1038/hr.2010.154
M3 - Article
C2 - 20703235
AN - SCOPUS:78149303260
SN - 0916-9636
VL - 33
SP - 1129
EP - 1136
JO - Hypertension Research
JF - Hypertension Research
IS - 11
ER -