Burden of severe rotavirus diarrhea in indonesia

Yati Soenarto, T. Aman Abu, Achirul Bakri, Herman Waluya, Agus Firmansyah, Muzal Kadim, Iesje Martiza, Dwi Prasetyo, Nenny S. Mulyani, Titis Widowati, Soetjiningsih, I. Putu Gede Karyana, Wayan Sukardi, Joseph Bresee, Marc Alain Widdowson

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Globally, rotavirus is the leading cause of diarrhea-related hospitalizations and deaths among young children, but the burden of rotavirus disease in Indonesia is poorly documented. From January through December 2006, we conducted prospective surveillance (inpatient and outpatient) among children aged <5 years at 6 hospitals in 6 provinces of Indonesia, using standardized methodology. Of 2240 enrolled children hospitalized for diarrhea, 1345 (60%) were rotavirus positive. Of 176 children enrolled in outpatient clinics in 3 hospitals, 73 (41%) were rotavirus positive. Among children hospitalized for diarrhea, dehydration was more common among those who tested positive for rotavirus than among those who did not (91% vs 82%; P < .05), as was vomiting (86% vs 67%; P < .05). Children aged 6-23 months experienced 72% of all rotavirus episodes. Rotavirus prevalence increased slightly in the cool, dry season. The most commonly detected genotypes were G9 (30%) and P[6] (56%). G1P[6] and G9P[6] accounted for 34% and 21% of strains, respectively. A high proportion of genotype P[6] was detected, in combination with the common G types G1 and G9. Available rotavirus vaccines would likely be efficacious against the most common circulating strains, but continued monitoring of uncommon genotypes is needed.

Original languageEnglish
JournalJournal of Infectious Diseases
Volume200
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1 Nov 2009

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