TY - JOUR
T1 - Burden of severe rotavirus diarrhea in indonesia
AU - Soenarto, Yati
AU - Abu, T. Aman
AU - Bakri, Achirul
AU - Waluya, Herman
AU - Firmansyah, Agus
AU - Kadim, Muzal
AU - Martiza, Iesje
AU - Prasetyo, Dwi
AU - Mulyani, Nenny S.
AU - Widowati, Titis
AU - Soetjiningsih,
AU - Karyana, I. Putu Gede
AU - Sukardi, Wayan
AU - Bresee, Joseph
AU - Widdowson, Marc Alain
N1 - Funding Information:
Supplement sponsorship: This article was published as part of a supplement entitled “Global Rotavirus Surveillance: Preparing for the Introduction of Rotavirus Vaccines,” which was prepared as a project of the Rotavirus Vaccine Program, a partnership between PATH, the World Health Organization, and the US Centers for Disease Control and Prevention, and was funded in full or in part by the GAVI Alliance.
Funding Information:
Ethical considerations. This study was approved by the Ethical Committee of Research in Medical Health at Faculty of Medicine, Gadjah Mada University, and by PATH (Seattle, Washington). Informed consent was obtained from parents or caretakers of eligible children before enrollment in the study.
PY - 2009/11
Y1 - 2009/11
N2 - Globally, rotavirus is the leading cause of diarrhea-related hospitalizations and deaths among young children, but the burden of rotavirus disease in Indonesia is poorly documented. From January through December 2006, we conducted prospective surveillance (inpatient and outpatient) among children aged <5 years at 6 hospitals in 6 provinces of Indonesia, using standardized methodology. Of 2240 enrolled children hospitalized for diarrhea, 1345 (60%) were rotavirus positive. Of 176 children enrolled in outpatient clinics in 3 hospitals, 73 (41%) were rotavirus positive. Among children hospitalized for diarrhea, dehydration was more common among those who tested positive for rotavirus than among those who did not (91% vs 82%; P < .05), as was vomiting (86% vs 67%; P < .05). Children aged 6-23 months experienced 72% of all rotavirus episodes. Rotavirus prevalence increased slightly in the cool, dry season. The most commonly detected genotypes were G9 (30%) and P[6] (56%). G1P[6] and G9P[6] accounted for 34% and 21% of strains, respectively. A high proportion of genotype P[6] was detected, in combination with the common G types G1 and G9. Available rotavirus vaccines would likely be efficacious against the most common circulating strains, but continued monitoring of uncommon genotypes is needed.
AB - Globally, rotavirus is the leading cause of diarrhea-related hospitalizations and deaths among young children, but the burden of rotavirus disease in Indonesia is poorly documented. From January through December 2006, we conducted prospective surveillance (inpatient and outpatient) among children aged <5 years at 6 hospitals in 6 provinces of Indonesia, using standardized methodology. Of 2240 enrolled children hospitalized for diarrhea, 1345 (60%) were rotavirus positive. Of 176 children enrolled in outpatient clinics in 3 hospitals, 73 (41%) were rotavirus positive. Among children hospitalized for diarrhea, dehydration was more common among those who tested positive for rotavirus than among those who did not (91% vs 82%; P < .05), as was vomiting (86% vs 67%; P < .05). Children aged 6-23 months experienced 72% of all rotavirus episodes. Rotavirus prevalence increased slightly in the cool, dry season. The most commonly detected genotypes were G9 (30%) and P[6] (56%). G1P[6] and G9P[6] accounted for 34% and 21% of strains, respectively. A high proportion of genotype P[6] was detected, in combination with the common G types G1 and G9. Available rotavirus vaccines would likely be efficacious against the most common circulating strains, but continued monitoring of uncommon genotypes is needed.
UR - http://www.scopus.com/inward/record.url?scp=72849128524&partnerID=8YFLogxK
U2 - 10.1086/605338
DO - 10.1086/605338
M3 - Article
C2 - 19821711
AN - SCOPUS:72849128524
SN - 0022-1899
VL - 200
SP - S188-S194
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - SUPPL. 1
ER -
