Bromelain encapsulation on hydrogel chitosan-poly(N-vinyl pirrolidone) full-IPN

Palagan Paksina Sandhy, Emil Budianto, Sumi Hudiyono Pws

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

Bromelain is an enzymes that has many benefits when absorbed in intestine. However bromelain is damaged pH of the gastric, so bromelain should be coated to passing through the pH of the gastric and could be released in the intestine. Full-Interpenetrating Network oh hydrogel of chitosan-poly(N-vinyl pyrolidone) is selected to encapsulate bromelain and then release bromelain in intestine. The average efficiency of post encapsulation of full-IPN hydrogel chitosan-poly(N-vinyl pyrolidone) full-IPN by Lowry method is obtained 99%. While the in vitro average disolution value of bromelain by using lowry method at pH 7,4 and at pH 1,2 and then at pH of 7,4 consecutively 24,11%, 25,8% and 13,57% respectively. Specific of the bromelain which is in vitro released at pH 7,4 is decreased 47,23%. The specific activity of bromelain is determined by using kunitz method.

Original languageEnglish
Title of host publication3rd International Seminar on Chemistry
Subtitle of host publicationGreen Chemistry and Its Role for Sustainability
EditorsFredy Kurniawan, Yuly Kusumawati, Sri Fatmawati, Hendro Juwono, Adi Setyo Purnomo
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735417755
DOIs
Publication statusPublished - 14 Dec 2018
Event3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018 - Surabaya, Indonesia
Duration: 18 Jul 201819 Jul 2018

Publication series

NameAIP Conference Proceedings
Volume2049
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Seminar on Chemistry: Green Chemistry and Its Role for Sustainability, ISOC 2018
Country/TerritoryIndonesia
CitySurabaya
Period18/07/1819/07/18

Keywords

  • bromelain
  • chitosan
  • hydrogel
  • kunitz
  • lowry

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