Bone regeneration during distraction osteogenesis

Lisa Rinanda Amir, Vincent Everts, Antonius L.J.J. Bronckers

Research output: Contribution to journalReview articlepeer-review

39 Citations (Scopus)


Bone has the capacity to regenerate in response to injury. During distraction osteogenesis, the renewal of bone is enhanced by gradual stretching of the soft connective tissues in the gap area between two separated bone segments. This procedure has received much clinical attention as a way to correct congenital growth retardation of bone tissue or to generate bone to fill skeletal defects. The process of bone regeneration involves a complex system of biological changes whereby mechanical stress is converted into a cascade of signals that activate cellular behavior resulting in (enhanced) formation of bone. Over the last decade, significant progress has been made in understanding the bone regeneration process during distraction osteogenesis. The mechanical and biological factors that are important for the success of the distraction treatment have been partially characterized and are discussed in this review.

Original languageEnglish
Pages (from-to)63-75
Number of pages13
Issue number2
Publication statusPublished - 2009


  • Angiogenesis
  • Bone regeneration
  • Mechanical stimulation
  • Review


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